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抗Rat (Rattus) FBXW7 抗体:
抗Human FBXW7 抗体:
抗Mouse (Murine) FBXW7 抗体:
Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012
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Human Polyclonal FBXW7 Primary Antibody for ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013
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Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015
Human Polyclonal FBXW7 Primary Antibody for IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. in The EMBO journal 2015
Human Monoclonal FBXW7 Primary Antibody for IHC, WB - ABIN2720979
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. in International journal of oncology 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014
Data showed that both chemo and radiation sensitivity increased in TE-8 and KYSE140 cells overexpressing FBXW7 compared with mock cells because of the degradation of the anti-apoptotic protein MCL1 (显示 MCL1 抗体).
Fbw7 mutations shifted cellular metabolism toward oxidative phosphorylation and caused context-specific metabolic vulnerabilities.
TINCR suppressed proliferation and invasion through regulating miR (显示 MLXIP 抗体)-544a/FBXW7 axis in lung cancer.
Low FBXW7 expression is associated with non-small cell lung cancer.
we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR (显示 MLXIP 抗体)-25 in esophageal squamous cell carcinoma (ESCC). In conclusion, the present study supports the potential of miR (显示 MLXIP 抗体)-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC
FBXW7 was significantly downregulated in renal cell carcinoma (显示 MOK 抗体) cell lines. Upregulation of FBXW7 in 786-O and ACHN (显示 LARP6 抗体) cell lines significantly inhibited cell migration, invasion and EMT (显示 ITK 抗体).
FBXW7 missense mutation is associated with metastatic colorectal adenocarcinoma.
miR (显示 MLXIP 抗体)-92b-3p inhibition prevented colorectal cancer proliferation, invasion, and migration by upregulating FBXW7, which might suggest the potential role of miR (显示 MLXIP 抗体)-92b-3p in colorectal carcinogenesis and metastasis.
FBXW7 is markedly downregulated in the liver of obese subjects. A functional low-frequency human FBXW7 coding variant ( (显示 AHSG 抗体)p.Ala204Thr) is associated with elevated blood glucose and T2DM risk in a Chinese population. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
Our findings suggest FBW7 mutational status and Mcl-1 (显示 MCL1 抗体) stability as key determinants of response to Hsp90 (显示 HSP90 抗体) inhibitors, which provides a rationale for using FBW7 genotype for potential patient stratification, and for drug combinations with Hsp90 (显示 HSP90 抗体) inhibitors that can effectively overcome Mcl-1 (显示 MCL1 抗体)-mediated resistance.
FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A (显示 AHSG 抗体) to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
the regulatory crosstalk between KLF5 (显示 KLF5 抗体), miR (显示 MLXIP 抗体)-29a, and Fbw7/CDC4 cooperatively promotes atherosclerotic development
found that Fbw7 loss caused activation of NF-kappaB (显示 NFKB1 抗体) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (显示 NFKB1 抗体) pathway.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (显示 HLCS 抗体)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (显示 NOTCH2 抗体) pathway as observed in patients with HCS (显示 HLCS 抗体).
The findings reveal a PLK1 (显示 PLK1 抗体)-Fbw7-Myc (显示 MYC 抗体) signaling circuit that underlies tumorigenesis and validate PLK1 (显示 PLK1 抗体) inhibitors, alone or with Bcl2 (显示 BCL2 抗体) antagonists, as potential effective therapeutics for MYC (显示 MYC 抗体)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (显示 YAP1 抗体)-dependent mechanism.
Study identifies a REV-ERBalpha (显示 NR1D1 抗体) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (显示 CDK1 抗体)) phosphorylation of REV-ERBalpha (显示 NR1D1 抗体) is recognized by the F-box protein (显示 FBXO30 抗体), FBXW7alpha, to direct REV-ERBalpha (显示 NR1D1 抗体) degradation via the proteasome. Disruption of this CDK1 (显示 CDK1 抗体)-FBXW7-mediated REV-ERBalpha (显示 NR1D1 抗体) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (显示 FRAP1 抗体) pathway in radiation-induced mouse thymic lymphomas.
Prion (显示 PRNP 抗体) infection induced the expression of FBXW7 in brain.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30