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Data suggest that Fas (显示 FAS 蛋白) and TNFR1 are involved in glaucoma mechanisms in cornea; pro-apoptotic effect of anti-glaucoma medication clonidine on corneal epithelial cells triggers Fas (显示 FAS 蛋白)/TNFR1-mediated, mitochondria-dependent signaling pathway. (Fas (显示 FAS 蛋白) = Fas (显示 FAS 蛋白) cell surface death receptor ; TNFR1 = TNF (显示 TNF 蛋白) receptor superfamily member 1A)
These results indicate that TNFRI-Fc and hHO-1 overexpression may apparently induce free iron in the liver and exert oxidative stress by enhancing reactive oxygen species production and block normal postneonatal liver metabolism.
Data suggest that elevated serum levels of soluble TNF (显示 TNF 蛋白) receptors, especially sTNFR1, are associated with loss of kidney function in Hispanic patients with diabetes type 2 in Colombia.
Case Report: heterozygous missense variants in TNFRSF1A identified in family members with familial Mediterranean fever (显示 MEFV 蛋白).
Case Report: autoinflammatory syndrome with relapsing aseptic neutrophilic meningitis and chronic myelitis associated with MEFV (显示 MEFV 蛋白)/TNFRSF1A mutations.
In this article we will review the role of ubiquitination and proteolysis in these diverse events focusing on our own contributions to the lysosomal apoptotic pathway linked to the subcellular compartmentalization of TNF-R1
Coadministration of either ATROSAB or EHD2 (显示 EHD2 蛋白)-scTNFR2 into the magnocellular nucleus basalis significantly protected cholinergic neurons and their cortical projections against cell death, and reverted the neurodegeneration-associated memory impairment in a passive avoidance paradigm. Simultaneous blocking of TNFR1 and TNFR2 (显示 TNFRSF1B 蛋白) signaling, however, abrogated the therapeutic effect
after 14 days of glucocorticoid therapy, clinical findings (serum bilirubin, skin GVHD) and plasma biomarkers (TIM3, ST2, sTNFR1) can predict failure of GVHD treatment and nonrelapse mortality.
Data show that interleukin-2 receptor alpha (显示 IL2RA 蛋白), tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 (显示 IL1RL1 蛋白) gene product), and regenerating islet-derived 3-alpha (显示 REG3A 蛋白) were significantly associated with non-relapse mortality.
Report of a severe case of TRAPS associated with a novel mutation, Thr90Pro, in the TNFRSF1A gene in an infant and several family members.
These findings indicate that TNFR1 is structurally positioned to modulate postsynaptic signaling in the PVN, suggesting a mechanism whereby TNFR1 activation contributes to cardiovascular and other autonomic functions.
Increased TNFR1 expression and signaling in injured peripheral nerves of mice with reduced BACE1 (显示 BACE 蛋白) activity
Results show that interleukin 6 (IL6 (显示 IL6 蛋白)) promotes oval cell proliferation and liver regeneration, while tumor necrosis factor alpha (TNFalpha (显示 TNF 蛋白)) and TNF (显示 TNF 蛋白) receptor-1(TNFR1) do not affect this process.
Data suggest that dietary treatment with green tea extract reduces hepatic inflammation in non-alcoholic fatty liver disease by decreasing proinflammatory signaling in liver through Tnfr1 (tumor necrosis factor (显示 TNF 蛋白) receptor superfamily, member 1a) and Tlr4 (toll-like receptor 4 (显示 TLR4 蛋白)) that otherwise increases NFkappaB activation and liver injury.
Genetic deletion of TNFR1 completely blocks TNF-alpha (显示 TNF 蛋白)-induced inflammation and reduces allergen-induced inflammation. Preserved electro-olfactogram responses suggest a TNFR1-dependent mechanism of TNF-alpha (显示 TNF 蛋白)-induced olfactory neuron dysfunction.
This work uncovers a dichotomy of function for TNFR2 (显示 TNFRSF1B 蛋白) in myeloid cells, with microglial TNFR2 (显示 TNFRSF1B 蛋白) providing protective signals to contain disease and monocyte/macrophagic TNFR2 (显示 TNFRSF1B 蛋白) driving immune activation and experimental autoimmune encephalomyelitis initiation.
The deficiency of TNFRp55 promoted the development of endometriosis.
TNFalpha (显示 TNF 蛋白) enhanced murine NK cell IFNgamma production via TNFR2 (显示 TNFRSF1B 蛋白) in vitro
TNFR2 (显示 TNFRSF1B 蛋白) sensitizes macrophages for endogenous TNF (显示 TNF 蛋白)-induced TNFR1-mediated necroptosis
this study shows that epithelial TNFR1 signaling promotes mucosal repair in inflammatory bowel disease
Retinal ischemia results in increased expression of TNF-alpha (显示 TNF 蛋白) and its receptors (TNF-R1 and TNF-R2 (显示 TNFRSF1B 蛋白)).
Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 蛋白) in zebrafish embryos results in the induction of a caspase-8 (显示 CASP8 蛋白), caspase-2 (显示 CASP2 蛋白) and P53 (显示 TP53 蛋白)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 蛋白).
These results suggest that TNF-alpha (显示 TNF 蛋白) sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII (显示 TNFRSF1B 蛋白) are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (显示 TNF 蛋白)) and its receptors (TNFRI and TNFRII (显示 TNFRSF1B 蛋白)) mRNAs and proteins, were determined.
The upregulation of TNFRI mRNA expression by IFNG (显示 IFNG 蛋白) suggests that TNF (显示 TNF 蛋白) and IFNG (显示 IFNG 蛋白) synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
TNF (显示 TNF 蛋白) binding induces release of AIP1 (DAB2IP (显示 DAB2IP 蛋白)) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD (显示 TRADD 蛋白), RIP1 (显示 RALBP1 蛋白), TRAF2 (显示 TRAF2 蛋白), and AIPl.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
, tumor necrosis factor binding protein 1
, tumor necrosis factor receptor 1A isoform beta
, tumor necrosis factor receptor superfamily member 1A
, tumor necrosis factor receptor type 1
, tumor necrosis factor-alpha receptor
, TNF receptor alpha chain
, tumor necrosis factor receptor 1
, tumor necrosis factor receptor type I
, p55 TNF receptor
, tumor necrosis factor receptor p60
, TNF Receptor 1 (TR1)
, tumor necrosis factor type I
, tumor necrosis factor receptor superfamily, member 1A
, tumor necrosis factor receptor superfamily member 1A-like