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|抗原||Insulin (INS) 抗体|
|适用||猫, 牛, 犬, 豚鼠, 马, 人, 猪, 兔, 大鼠, 绵羊 其他选择|
|标记||This Insulin antibody is un-conjugated 其他选择|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Insulin抗体详情Insulin目标详情 使用细节 贮存及处理 References for anti-Insulin antibody (ABIN114751) 图像
This antibody recognizes purified Insulin from the pancreas of Human, Bovine, Horse, Sheep as well as Proinsulin from Human. Cross reaction has been observed with insulin containing cells in fixed sections of pancreas from Human, Porcine, Dog, Rabbit, Bovine, Sheep, Rat, Guinea Pig and Cat.
Cellular Localization: Cytoplasmic.Cellular Localization
Insulin目标详情Insulin抗体详情 使用细节 贮存及处理 References for anti-Insulin antibody (ABIN114751) 图像 回页首
|别名||Insulin (INS Antibody 摘要)|
|背景||Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.Synonyms: INS|
|途径||NF-kappaB Signaling, RTK signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation|
使用细节Insulin抗体详情 Insulin目标详情 贮存及处理 References for anti-Insulin antibody (ABIN114751) 图像 回页首
Immunohistochemistry on Formalin/Paraffin Sections: Use a dilution of 1/25-1/50 in anABC method (30 minutes at room temperature). Recommended Positive Control: Pancreas.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理Insulin抗体详情 Insulin目标详情 使用细节 References for anti-Insulin antibody (ABIN114751) 图像 回页首
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||4 °C/-20 °C|
|储存方法||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-Insulin antibody (ABIN114751)Insulin抗体详情 Insulin目标详情 使用细节 贮存及处理 图像 回页首
Madsen: "Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion." in: Diabetes, Vol. 36, Issue 10, pp. 1203-11, 1987
Keilacker, Dietz, Witt, Woltanski, Berling, Ziegler: "Kinetic properties of monoclonal insulin antibodies." in: Biomedica biochimica acta, Vol. 45, Issue 8, pp. 1093-102, 1986