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Buffalo (Bubalus) Polyclonal Insulin Primary Antibody for IEM, ICC - ABIN617877
Tay, Wong: Insulin-like immunoreactivity in the monkey spinal cord. in Acta anatomica 1992
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Human Monoclonal Insulin Primary Antibody for IHC (p) - ABIN3043651
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats. in Experimental biology and medicine (Maywood, N.J.) 2009
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Cow (Bovine) Monoclonal Insulin Primary Antibody for CyTOF, FACS - ABIN4900790
Cucak, Grunnet, Rosendahl: Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. in Journal of leukocyte biology 2014
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Cow (Bovine) Monoclonal Insulin Primary Antibody for FACS - ABIN4898619
Kalis, Bolmeson, Esguerra, Gupta, Edlund, Tormo-Badia, Speidel, Holmberg, Mayans, Khoo, Wendt, Eliasson, Cilio: Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. in PLoS ONE 2012
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Human Polyclonal Insulin Primary Antibody for EIA, FACS - ABIN372838
Madsen, Knauf, Gotfredsen, Pilling, Sjögren, Andersen, Andersen, de Boer, Manova, Barlas, Vundavalli, Nyborg, Knudsen, Moelck, Fagin: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. in Endocrinology 2012
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Human Monoclonal Insulin Primary Antibody for ELISA (Capture), ELISA - ABIN617624
Back, Scheuner, Han, Song, Ribick, Wang, Gildersleeve, Pennathur, Kaufman: Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. in Cell metabolism 2009
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Human Monoclonal Insulin Primary Antibody for ELISA (Capture), ELISA - ABIN617623
Kojima, Fujimiya, Matsumura, Nakahara, Hara, Chan: Extrapancreatic insulin-producing cells in multiple organs in diabetes. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Identify a novel proinsulin-associated locus and demonstrate that whilst proinsulin levels are associated with carotid intima media thickness measures, proinsulin per se is unlikely to have a causative effect on cIMT.
Data suggest that both a KATP channel-dependent triggering pathway (that induces a [Ca2 (显示 CA2 抗体)+]i rise in beta-cells) and an amplifying pathway (that augments the effect of Ca2 (显示 CA2 抗体)+ on exocytosis) are crucial for control of insulin secretion in human islets; these studies used cultured pancreatic islets from multiorgan donors exposed to a variety of pharmacological agents.
In the present study, the protein inhibitor of activated STAT (显示 STAT1 抗体) Y (PIASy (显示 PIAS4 抗体)) was identified as a novel Isl1 (显示 ISL1 抗体)-interacting protein. Furthermore, PIASy (显示 PIAS4 抗体) and Isl1 (显示 ISL1 抗体) upregulate insulin gene expression and insulin secretion in a dose-dependent manner by activating the insulin promoter.
Muscle-related indices positively correlated with C-peptide, which showed endogenous insulin reserve
Data suggest that corticosterone and cortisol suppress voltage-dependent Ca2+ channel function and Ca2+ fluxes in beta-cells; however, insulin secretion, maximal ATP/ADP responses to glucose, and beta-cell identity/differentiation are all unaffected by these glucocorticoids.
In long-standing models, glucose is viewed as a primary stimulator of insulin secretion; recent models postulate that glucose activates a cell-surface receptor, namely the glucose-sensing receptor, on insulin-secreting cells. [REVIEW]
Data suggest that beta-cell insulin secretory granules, unlike neuronal synaptic vesicles, exhibit biphasic secretory mechanism that requires additional distinct features in exocytosis; beta-cell insulin exocytotic events appear to be mediated by Munc18/SNARE (显示 NAPA 抗体) protein complexes distinct from those involved in predocking/fusion of insulin secretory granules with plasma membrane. [REVIEW]
Data suggest that glucose-stimulated insulin secretion involves interplay between metabolic and cationic events involving small G-proteins; activation of these signaling proteins promotes cytoskeletal remodeling, transport and docking of insulin granules on the plasma membrane for exocytotic secretion of insulin. [REVIEW]
Data suggest that insulin secretory granule turnover consists of several highly regulated processes allowing for proper beta-cell function and insulin secretion. [REVIEW]
Data suggest that cAMP acts as amplifier of insulin secretion triggered by Ca2 (显示 CA2 抗体)+ elevation in beta-cells; both messengers are also positive modulators of glucagon (显示 GCG 抗体) release from alpha-cells, but in this case cAMP signaling may be the important regulator and Ca2 (显示 CA2 抗体)+ signaling has a more permissive role. [REVIEW]
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (显示 ATP1A1 抗体) activity and SFK signaling.
PTPLAD1 (显示 PTPLAD1 抗体) and AMPK (显示 PRKAA1 抗体) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (显示 ATIC 抗体) later accumulates in the Golgi/endosome fraction.
Pdx-1 (显示 PDX1 抗体), MafA (显示 MAFA 抗体) and NeuroD1 (显示 NEUROD1 抗体) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (显示 TNF 抗体) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (显示 PPARG 抗体), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (显示 IGF1 抗体) levels are less easily modified.
insulin increased GCLc (显示 GCLC 抗体) promoter activity, which required a prerequisite increase or decrease in medium glucose
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (显示 LEP 抗体)-NPY (显示 NPY 抗体) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (显示 VMP1 抗体)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (显示 FRAP1 抗体) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.
insulin supports early initiation of the mesodermal factor Brachyury (显示 TBX1 抗体) and the signalling molecules Wnt3a (显示 WNT3A 抗体) and Wnt4 (显示 WNT4 抗体) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
Data (including data from studies using knockout mice) suggest that Ins1 and Ins2 are required for pancreatic beta-cell maturation; thus, Ins1 and Ins2 are needed for normal beta-cell development and for maintenance of normal beta-cell function.
cTAGE5 (显示 CTAGE5 抗体) deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (显示 Actbeta 抗体) activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (显示 SOX2 抗体)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.
have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (显示 GHRL 抗体) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (显示 GHSR 抗体) in the central nervous system and partly involved in carbohydrate-glycogen (显示 GYS2 抗体) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.