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IL1B (显示 IL1B 蛋白) regulates expression of IL1R1 (显示 IL1RN 蛋白) and IL1RAP and stimulates expression of PTGS1 (显示 PTGS1 蛋白) and PTGS2 (显示 PTGS2 蛋白) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (显示 PLIN1 蛋白)-implantation period of pregnancy in pigs.
Reconstitution of ST2 (显示 SULT2A1 蛋白) (IL-1R4) specific for IL-33 (显示 IL33 蛋白) activity; no suppression by IL-1Ra (显示 IL1RN 蛋白) though a common chain IL-1R3 (IL-1RAcP) shared with IL-1 (显示 IL1A 蛋白).
These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells.
single nucleotide polymorphism A471T in the Toll (显示 TLR4 蛋白)-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 (显示 IL1RL2 蛋白) that is present in approximately 2% of the human population, down-regulated IL-36R (显示 IL1RL2 蛋白) signaling by a decrease of interaction with IL-1RAcP.
The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework.
The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk.
Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis.
Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 (显示 SULT2A1 蛋白) possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution.
MARCH8 (显示 MARCH8 蛋白)-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta (显示 IL1B 蛋白)-induced signaling pathways.
Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML (显示 RUNX1 蛋白) cells.
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt (显示 AKT1 蛋白) kinase.
These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1 (显示 IL1RAPL1 蛋白)/IL-1RAcP.
In experimental biliary atresia, miR (显示 MLXIP 蛋白)-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 (显示 IGF1 蛋白) and Il1RAP are down-regulated by miR (显示 MLXIP 蛋白)-29.
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.
IL-1RAcP is essential for physiological activities of peripheral IL-1 (显示 IL1A 蛋白).
Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling
data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 (显示 IL1A 蛋白) complex by binding to epitopes on domain III of the IL-1RI created following IL-1 (显示 IL1A 蛋白) binding to the IL-1RI
IL-33 (显示 IL33 蛋白) and ST2 (显示 SULT2A1 蛋白) form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex.
IL-1RAcP is used by more than one alpha-chain (显示 FCGRT 蛋白) of the IL-1 (显示 IL1A 蛋白) receptor family and thus may resemble a common beta-chain (显示 CSF2RB 蛋白) of that family
these observations establish AcP (显示 NDUFAB1 蛋白) as co-receptor for IL-33 (显示 IL33 蛋白) signaling via ST2 (显示 SULT2A1 蛋白) and suggest a novel role for sAcP in modulating the biological activity of IL-33 (显示 IL33 蛋白)
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
interleukin 1 receptor accessory protein
, interleukin-1 receptor accessory protein
, interleukin-1 receptor accessory protein-like
, IL-1 receptor accessory protein
, interleukin-1 receptor 3
, interleukin-1 receptor accessory protein beta