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these results reveal that the IL-1 (显示 IL1A 蛋白)/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of ulcerative colitis patients
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (显示 IL1B 蛋白) rs16944, IL1R2 rs2071008, PLA2G7 (显示 Lp-PLA2 蛋白) rs9395208, FAM5C rs12732361, CD40 (显示 CD40 蛋白) rs1800686, and CD36 (显示 CD36 蛋白) rs2065666 were associated with coronary heart disease (CHD (显示 CHDH 蛋白)), suggesting an important role of inflammation in the risk of CHD (显示 CHDH 蛋白).
Expression level of IL1R2 was down regulated in cervical squamous cell carcinoma.
No significant differences in the lymphocyte mRNA levels of IL-1R2, IL-6R, and Gp130 were observed between MDD patients and NC. These studies suggest abnormal gene expression of these cytokines and their membrane-bound receptors in the lymphocytes of MDD patients, and that their mRNA expression levels in the lymphocytes could be a useful biomarker for depression.
IL1R2 rs2310173 genotype GT was mildly protective against ankylosing spontylitis only in HLA-B27-negative patients.
IL1R2 hypomethylation and androgen receptor (显示 AR 蛋白) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (显示 NPRL2 蛋白) hypomethylation and SP140 (显示 SP140 蛋白) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with ankylosing spondylitis in Northern Han Chinese.
Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6 (显示 IL6 蛋白)) and vascular endothelial growth factor A (VEGF-A (显示 VEGFA 蛋白)) promoters.
Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6 (显示 IL6 蛋白), levels were positively correlated with a composite measure of aggression.
results suggested that IL1R2 could have oncogenic potential in osteosarcoma
Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta (显示 IL1B 蛋白)-induced AMP (显示 TMPRSS5 蛋白) production.
Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1 (显示 IL1A 蛋白)- and neutrophil-dependent tissue inflammation
Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17 (显示 ADAM17 蛋白)) regulates interleukin (IL)-1 (显示 IL1A 蛋白) signaling via cleavage of IL-1 (显示 IL1A 蛋白) receptor type 2 (IL-1R2).
IL-1 (显示 IL1A 蛋白) receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 (显示 IL1A 蛋白) signal on macrophages.
Interleukin-1 receptor type II is significantly upregulated in decidual cells close to the embryo during days 5 to 8 of pregnancy.
Data show that bee venom detected by inflammasome and trigger activation of caspase-1 (显示 CASP1 蛋白) and secretion of proinflammatory cytokine IL-1beta (显示 IL1B 蛋白) is pyrin domain-containing 3 NLRP3 (显示 NLRP3 蛋白), apoptosis-associated speck-like protein ASC (显示 STS 蛋白), and IL-1 (显示 IL1A 蛋白) receptor dependent.
inoculation of young CD4 (显示 CD4 蛋白)(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4 (显示 CD4 蛋白)(+) T cells and reduced age-related hearing loss
BACE1 (显示 BACE 蛋白) and BACE2 (显示 BACE2 蛋白) may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (显示 APP 蛋白)
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
interleukin-1 receptor type 2
, soluble type II IL-1 receptor
, CD121 antigen-like family member B
, IL-1 type II receptor
, antigen CDw121b
, interleukin 1 receptor type II variant 3
, interleukin-1 receptor beta
, interleukin-1 receptor type II
, type II interleukin-1 receptor, beta
, IL-1 receptor beta chain