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Cow (Bovine) Growth Hormone 1 Protein expressed in - ABIN621622
Wang, Ji, Wang, Chen, Wang, Loor: The preliminary study on the effects of growth hormone and insulin-like growth factor-I on κ-casein synthesis in bovine mammary epithelial cells in vitro. in Journal of animal physiology and animal nutrition 2016
Human Growth Hormone 1 Protein expressed in Escherichia coli (E. coli) - ABIN803848
Mano-Otagiri, Nemoto, Sekino, Yamauchi, Shuto, Sugihara, Oikawa, Shibasaki et al.: Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ... in Endocrinology 2006
Single nucleotide variant in GH1 gene is associated with isolated growth hormone deficiency.
In newborns, serum PRL (显示 PRL 蛋白) and hGH levels show a positive correlation that can be explained by common regulatory factors or a drift phenomenon. A higher gestational week is associated with a higher PRL (显示 PRL 蛋白)/hGH ratio.
This review describes the endocrine profile of centenarians concerning the GH/IGF-I (显示 IGF1 蛋白)/insulin (显示 INS 蛋白) system, focusing on the relevance of this pathway on the modulation of ageing and longevity.
Data suggest that patients with NICTH (non-islet cell tumor hypoglycemia) exhibit low serum growth hormone levels during hypoglycemic episodes. [Retrospective Study & REVIEW of Case Reports]
Homozygous GH1 deletion is associated with growth hormone deficiency.
Human Growth Hormone Inhibits CLAUDIN-1 (显示 CLDN7 蛋白) Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3 (显示 STAT3 蛋白)).
GH1 and GHRHR screening revealed eleven variations in 24 (21%) patients with isolated growth hormone deficiency of which, four were novel deleterious, one novel non-pathogenic and six reported changes.
The results suggest that GH regulates energy metabolism directly in myocytes and that UCP2 (显示 UCP2 蛋白) participates in the signal transduction pathway that functions downstream of the GHR (显示 GHR 蛋白)/JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白).
These results implicate TIMP3 (显示 TIMP3 蛋白) as a modulator of cell surface GHR (显示 GHR 蛋白) abundance and the ability of GH to promote cellular signaling.
Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 (显示 NF1 蛋白) patients, similarly to central precocious puberty
These results indicate that up-regulation of GH in the lungs of DJ-1 (显示 PARK7 蛋白) KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
Confirmation of the impairment of GH-IGF-1 (显示 IGF1 蛋白) release in hyperphagic MC4R (显示 MC4R 蛋白) KO mice suggests a role for insulin (显示 INS 蛋白) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (显示 IGF1 蛋白) levels
When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 (显示 IGF1 蛋白) receptor were broadly protected from cell damage, neuroinflammation and cerebral edema.
Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys (显示 DNAJC5 蛋白) in the thiol reactant.
Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
alter miR (显示 MLXIP 蛋白)-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC (显示 FUT1 蛋白) migration
Moderate elevations in circulating GH and IGF-I (显示 IGF1 蛋白) can directly increase basal insulin (显示 INS 蛋白) secretion without impacting beta-cell mass, independent of changes in whole body insulin (显示 INS 蛋白) sensitivity and hyperlipidemia.
Acylated ghrelin (显示 GHRL 蛋白) is not required for the surge in pituitary growth hormone observed in pregnant mice.
STAT5 (显示 STAT5A 蛋白) signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.
bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 (显示 FGF21 蛋白) levels were significantly elevated in bGH mice. Expression of Fgf21 (显示 FGF21 蛋白), Fgfr1 (显示 FGFR1 蛋白), and Klb (显示 KLB 蛋白) mRNA in white AT and liver were downregulated or unchanged in bGH mice.
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN (显示 MSTN 蛋白)/DraI.
An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.
The association of IGF1 (显示 IGF1 蛋白), GH, and PIT1 (显示 POU1F1 蛋白) markers with growth and reproductive traits were assessed.
The total frequencies for the combined genotypes for the bGH and RORC (显示 RORC 蛋白) genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
Whereas only moderate structural changes were observed with up-regulation of GH/IGF-I (显示 IGF1 蛋白) axis, disruption of the GH receptor (显示 GHR 蛋白) had pronounced effects upon tendon ultra-structure.
this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL (显示 PRL 蛋白) gene transcription in dairy cow anterior pituitary cells
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 (显示 POU1F1 蛋白) gene (AB) was desirable
one GH1 SNP, GH33, was significantly associated with milk protein (显示 CSN2 蛋白) yield in the second lactation. Several GH1 SNPs were significantly associated with fertility.
GH and IGF-I (显示 IGF1 蛋白) genotypes had no substantial effect on productive parameters, though IGF-I (显示 IGF1 蛋白) genotype affected calving-first service interval in primiparous cows. However, the genotypes do alter the endocrine/metabolic profiles of the transition dairy cow.
Data indicate that the dual effects of cortistatin (显示 CORT 蛋白) on growth hormone release parallel those of somatostatin (显示 SST 蛋白) and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.
ghrelin increased growth hormone secretion but not growth hormone synthesis by ovarian follicles
Plasma levels of growth hormone (as well as glucose, insulin (显示 INS 蛋白), and leptin (显示 LEP 蛋白)) are highly correlated with the duration of winter anovulatory phase.
Expression of PRL (显示 PRL 蛋白) and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL (显示 PRL 蛋白) and GH for other species.
Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR (显示 GHR 蛋白) excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.
that concomitant overexpression of GH and GHR (显示 GHR 蛋白) resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1 (显示 STAT5B 蛋白).
Effects of somatotrophic axis (GH/GHR (显示 GHR 蛋白)) double transgenesis on structural and molecular aspects of the zebrafish immune system
The zebrafish gh1 mutant, vizzini, exhibits decreased somatic growth, increased adipose tissue accumulation, and disrupted adipose plasticity after nutrient deprivation.
tbx5 (显示 TBX5 蛋白) knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis
Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1 (显示 IGF1 蛋白)) responses in both Atlantic salmon and rainbow trout.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
pituitary growth hormone
, growth hormone 12
, growth hormone
, growth hormone 1
, neural retina growth hormone
, Pituitary growth hormone
, growth hormone I
, Growth hormone
, growth hormone type a long isoform
, growth hormone type a short isoform
, growth hormone protein
, Growth hormone 1
, growth hormone B3
, growth hormone type 1