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抗Mouse (Murine) BCL3 抗体:
抗Human BCL3 抗体:
抗Rat (Rattus) BCL3 抗体:
Human Polyclonal BCL3 Primary Antibody for FACS, IF - ABIN653286
Kabuta, Hakuno, Cho, Yamanaka, Chida, Asano, Wada, Takahashi: Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity. in Biochemical and biophysical research communications 2010
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a sufficient concentration of Bcl3 in mouse embryonic stem cells plays a critical role in the maintenance of pluripotency and the self-renewal.
Thus, we concluded that fine-tuning expression of Bcl-3 is needed for proper CD4 (显示 CD4 抗体)(+) T-cell development and is required to sustain Th17-cell mediated pathology.
Bcl-3 suppressed colorectal tumor formation: Bcl-3-deficient mice were relatively protected from DSS (显示 PMP22 抗体)-induced epithelial damage and developed more polyps after AOM (显示 COL2A1 抗体)/DSS (显示 PMP22 抗体) treatment, although polyp size was unaffected.
this study implicates the intracellular protein (显示 CKAP2 抗体), BCL3, as a key mediator of the IL-10 (显示 IL10 抗体)-induced immunosuppressive macrophage phenotype
These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF (显示 LIF 抗体)/STAT3 (显示 STAT3 抗体) signaling in pluripotency maintenance.
Bcl3 reduces the inflammatory response in pancreas/biliary tissue by blocking ubiquitination and proteasome-mediated degradation of nuclear factor-kappaB p50 (显示 NFKB1 抗体) homodimers.
Low expression of IL-6 (显示 IL6 抗体) and TNF-alpha (显示 TNF 抗体) correlates with the presence of the nuclear regulators of NF-kappaB (显示 NFKB1 抗体), IkappaBNS (显示 NFKBID 抗体) and BCL-3, in the uterus of mice.
These findings demonstrate that Bcl-3 is required in dendritic cells to prime protective T-cell-mediated immunity to T. gondii
data show that BCL-3 makes extensive contacts with p50 (显示 LSP1 抗体) homodimers and in particular with ankyrin (显示 ANK 抗体) repeats (ANK) 1 (显示 ANK1 抗体), 6, and 7, and the N-terminal region of Bcl-3.
The presence of a p50 (显示 LSP1 抗体)/Bcl-3 complex in nuclear extracts from cells of metastatic lung tissues.
B-cell leukemia protein 3 (显示 HSPB3 抗体) (Bcl3) expressed in response to cytokine TWEAK (显示 TNFSF12 抗体) stimulation (experimental kidney injury) decreases TWEAK (显示 TNFSF12 抗体)-induced inflammatory and lethal responses.
Four gene signature (PTEN, PIK3C2A (显示 PIK3C2A 抗体), ITPA (显示 ITPA 抗体) and BCL3) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma (显示 MOK 抗体).
Akt2 (显示 AKT2 抗体), Erk2 (显示 MAPK1 抗体), and IKK1 (显示 CHUK 抗体)/2 phosphorylate Bcl3, converting Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.
Bcl-3 knockdown enhanced the degradation of Smad3 (显示 SMAD3 抗体) but not Smad2 (显示 SMAD2 抗体) following TGFbeta (显示 TGFB1 抗体) treatment.
We have shown for the first time that BCL-3 promotes the growth of colorectal cancer cells through activation of the AKT (显示 AKT1 抗体) pathway, increasing tumour cell yield both in vitro and in vivo.
BCL3 serves as an oncogene (显示 RAB1A 抗体) in glioma by modulating proliferation, cell cycle progression and apoptosis, and its oncogenic effects are mediated by the STAT3 (显示 STAT3 抗体) signaling pathway.
miR (显示 MLXIP 抗体)-19b silencing promoted cell proliferation and cell cycle progression in gastric cancer cells and BCL3 was identified as a direct target of miR (显示 MLXIP 抗体)-19b
Study confirmed that BCL-3 is overexpressed in hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) tissues and correlated with adverse clinicopathological features and poorer prognosis. BCL-3 can promote the growth of HCC (显示 FAM126A 抗体) cells by promoting cell viability, proliferation and cell cycle progression through regulation of CCND1 (显示 CCND1 抗体) expression.
Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
B-cell CLL/lymphoma 3
, B-cell leukemia/lymphoma 3
, B-cell lymphoma 3 protein homolog
, B-cell lymphoma 3 protein
, B-cell lymphoma 3-encoded protein
, chronic lymphatic leukemia protein
, proto-oncogene BCL3