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we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX (显示 ARHGEF7 蛋白) complex in health and disease
show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex
The novel recycling regulator alpha-PIX and the degradation factor c-Cbl (显示 CBL 蛋白) closely cooperate in the regulation of EGFR (显示 EGFR 蛋白) trafficking.
c-Cbl (显示 CBL 蛋白) negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl (显示 CBL 蛋白) in C6 and A172 glioma cells is responsible for their malignant behavior
results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl (显示 CBL 蛋白)-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl (显示 CBL 蛋白)(cos) cells.
These findings suggest that alpha Pix plays an important role in mutant huntingtin (显示 HTT 蛋白) aggregation.
The interaction of alphaPix with CagA (显示 S100A8 蛋白) activates PAK1 (显示 PAK1 蛋白), ERK (显示 EPHB2 蛋白) and NF-kappaB (显示 NFKB1 蛋白), which induces IL-8 (显示 IL8 蛋白) expression in H. pylori-infected gastric epithelial cells.
The plexin-B1 (显示 PLXNB1 蛋白)/Rac (显示 AKT1 蛋白) interaction inhibits PAK activation and enhances Sema4D (显示 SEMA4D 蛋白) ligand binding
Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation.
Data suggest that Rac (显示 AKT1 蛋白)-dependent activation of the NFkappaB (显示 NFKB1 蛋白) pathway may be a critical element promoting thrombin (显示 F2 蛋白)-induced tissue factor (显示 F3 蛋白) expression and activity, and thus a prothrombotic state in pulmonary hypertension.
this study has identified a new role for Parvin (显示 PARVA 蛋白) and alphaPix downstream of the integrin-ILK (显示 ILK 蛋白) signaling axis for mammary epithelial cell differentiation.
Enforced expression of miR-135a in highly tumorigenic cancer stem cells strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6.
Results indicate Arhgef6 (alphaPIX) as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection.
alphaPIX and GIT2 (显示 GIT2 蛋白) are required for neuronal differentiation.
suggest that imbalance in activity of different Rho GTPases may underlie altered neuronal connectivity and impaired synaptic function and cognition in alphaPix/Arhgef6 knockout mice
The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment.
ARHGEF6 is localized in dendritic spines where it contributes to regulate dendritic spine morphogenesis.
These results reveal specific roles for alphaPIX in the immune system and suggest that redundancy with betaPIX (显示 ARHGEF7 蛋白) precludes a more severe immune phenotype.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
PAK-interacting exchange factor alpha
, PAK-interacting exchange factor, alpha
, Rac/Cdc42 guanine exchange factor (GEF) 6
, rac/Cdc42 guanine nucleotide exchange factor 6
, rho guanine nucleotide exchange factor 6
, alpha PIX Rho GTPase guanine nucleotide exchange factor
, rac/cdc42 guanine nucleotide exchange factor 6