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抗Rat (Rattus) 抗体:
抗Mouse (Murine) 抗体:
Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731
Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b