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The meta-analysis showed that glutathione S-transferases GSTT1 (显示 GSTT1 蛋白) and GSTM1 null polymorphisms are risk factors for breast cancer [Meta-analysis].
individuals carrying GSTM1 null variant showed protective role against seizure.
Our meta-analysis supports that CYP1A1 (显示 CYP1A1 蛋白) exon7 polymorphism might contribute to individual susceptibility to esophageal cancer in the Chinese population. Gene-gene interaction analysis found a synergistic interaction between CYP1A1 (显示 CYP1A1 蛋白) mutation genotypes and GSTM1 deletion genotype.
The effects of GSTM1/GSTT1 (显示 GSTT1 蛋白) genes on diabetes mellitus type 2 risk are gender dependent and may be triggered by tobacco smoking.
GSTM1 gene polymorphism is associated with liver diseases.
Authors conclude that maternal GSTM1/GSTT1 (显示 GSTT1 蛋白) gene polymorphisms present an impact on birth weight, being involved in the neonatal nutritional status.
VEGF (显示 VEGFA 蛋白), VEGFR2 (显示 KDR 蛋白) and GSTM1 polymorphisms in outcome of multiple myeloma patients treated with thalidomide-based regimens
Based on our meta-analysis, the GSTM1 null genotype is a risk factor for CRC (显示 CALR 蛋白).
Indel variants of GSTM1 were typed in breast cancer patients and normal controls. GSTM1 deletion seemed to marginally increase breast cancer risk in Mexican women.
The current analyses suggests significant association was found between GSTM1 variants and the risk of childhood acute lymphoblastic leukemia (ALL), while no association were found between GSTT1 (显示 GSTT1 蛋白) and GSTP1 (显示 GSTP1 蛋白) Ile105Val polymorphism and childhood ALL risk
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (显示 NFE2L2 蛋白) regulation: cytochrome CYP2A5, GSTM3 (显示 GSTM3 蛋白), GSTM1, ENTPD5 (显示 ENTPD5 蛋白),UDPGDH (显示 UGDH 蛋白), and EPHX1 (显示 EPHX1 蛋白).
mitochondrial Gstb1 is induced under oxidative stress
the gene (GSTM1) encoding the detoxification enzyme glutathione S-transferase M1 is transcriptionally upregulated by Myb (显示 MYB 蛋白)
The Gstm1 gene was represented by two EST (显示 MAP3K8 蛋白) clones with similar levels of downregulation.
We overexpressed Hoxa9 (显示 HOXA9 蛋白) and Meis1 (显示 MEIS1 蛋白) in primary hematopoietic cells. Arrays identified c-Myb (显示 MYB 蛋白) and a c-Myb (显示 MYB 蛋白) target (Gstm1) among the genes with the strongest response to Hoxa9 (显示 HOXA9 蛋白)/Meis1 (显示 MEIS1 蛋白).
Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. In addition, oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
GST HB subunit 4
, GST class-mu 1
, HB subunit 4
, S-(hydroxyalkyl)glutathione lyase
, glutathione S-alkyltransferase
, glutathione S-aralkyltransferase
, glutathione S-aryltransferase
, glutathione S-transferase M1
, glutathione S-transferase Mu 1
, GST 3-3
, GST Yb1
, glutathione S-transferase Yb-1 subunit
, glutathione-S-transferase mu type 1 (Yb1)
, glutathione-S-transferase, mu type 1 (Yb1)
, GST 1-1
, glutathione S-transferase GT8.7
, glutathione-S-transferase, mu 1
, glutathione S-transferase mu 1
, glutathione S-transferase mu 2
, glutathione S-transferase, mu 2