Although no significant links were found between GST polymorphism and treatment response, null genotypes of GSTM1, GSTT1 and 'G' allele of GSTP1 bring a higher risk of severe gastrointestinal toxicity due to chemoradiation therapy in cervical cancer.
we did not detect any evident association between the GSTM1 present/null polymorphism and nasal or colorectal polyposis (NP or CP)risk.
oxidative damage induced by lipid peroxidation with reduced antioxidant capacity and genetic variants in GST genes (GSTM1/T1 and P1) may modify the risk of coronary artery disease development in Asian Indian population
GSTM1 Polymorphism is associated with Breast Cancer Risk.
The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A>G (Ile105Val), in diabetic nephropathy susceptibility.
The integrative assessment of clinical and cytogenetic parameters in the group of elderly capital ES, CyrillicAALB patients with mutant GSTM1 (0/0) allele, as compared with the other groups, enable to conclude that there are significant positive correlations between the indices of the severity disruption of articular locomotor function and the frequency of synovial fluid cells with trisomy of chromosome 7.
The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm).
Combinations of the Variant Genotypes of CYP1A1, GSTM1 and GSTT1 are Associated with an Increased Lung Cancer Risk in North Indian Population: a Case-Control Study.
GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity. [meta-analysis]
For glutathione S-transferase alpha 1 (GSTA1) and glutathione S-transferase mu 1 (GSTM1) polymorphisms, an association was observed with dietary fiber intake
the GSTM1-null, GSTT1-null and dual-null GSTM1-GSTT1 genotypes might be associated with the onset of bladder cancer (Meta-Analysis)
The GSTM1 polymorphism exhibited a highly significant association with physical performance in Korean population.
We determined that the T/T genotype is associated with a longer lifespan (OR = 5.972, 95% CI 1.798-19.833, p = 0.001, for all genders; p = 0.006 adjusted by gender). We also observed a significant difference (p < 0.05) in the distribution of alleles and genotypes in both the male group (TT vs. TA, OR = 1.043, 95% CI 1.022-1.067, p = 0.043) and the female group (TT vs. TA, OR = 3.592, 95% CI 0.982-13.147, p = 0.039)
GSTM1 null genotype increases the risk of pre-eclampsia;m combined GSTT1 and GSTM1 null genotype, makes the risk even higher in Bangladeshi women.
Our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to male infertility in Chinese populations
GSTM1-GSTT1-null genotype is associated with renal cell carcinoma susceptibility.
GSTM1-null genotype is associated with an increased bladder cancer risk in the Chinese individuals. [meta-analysis]
GSTM1 null genotype might be associated with an increased risk of developing oral cancer in individuals from Mainland but not from Taiwan China. [meta-analysis]
GSTM1 Polymorphism is associated with Nasopharyngeal Cancer.
The GSTM1-null genotype was more frequent among Javanese-Sundanese ethnics (99%) than among the Indonesian Malay (67.2%). Analysis of the combined distribution of the GSTM1 and GSTT1 genes revealed that 66.7% of the individuals from the Javanese-Sundanese population lack both the genes, whereas only 21.1% of the Indonesian Malay is GSTM1-null and GSTT1-null.
missense mutation (rs135955605) associated with significant decrease of sperm motility and ATP content
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
mitochondrial Gstb1 is induced under oxidative stress
the gene (GSTM1) encoding the detoxification enzyme glutathione S-transferase M1 is transcriptionally upregulated by Myb
The Gstm1 gene was represented by two EST clones with similar levels of downregulation.
We overexpressed Hoxa9 and Meis1 in primary hematopoietic cells. Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1.
Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. In addition, oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
GST HB subunit 4
, GST class-mu 1
, HB subunit 4
, S-(hydroxyalkyl)glutathione lyase
, glutathione S-alkyltransferase
, glutathione S-aralkyltransferase
, glutathione S-aryltransferase
, glutathione S-transferase M1
, glutathione S-transferase Mu 1
, GST 3-3
, GST Yb1
, glutathione S-transferase Yb-1 subunit
, glutathione-S-transferase mu type 1 (Yb1)
, glutathione-S-transferase, mu type 1 (Yb1)
, GST 1-1
, glutathione S-transferase GT8.7
, glutathione-S-transferase, mu 1
, glutathione S-transferase mu 1
, glutathione S-transferase mu 2
, glutathione S-transferase, mu 2