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Authors demonstrated that ER(alpha (显示 ESR1 蛋白)), GATA3 (显示 GATA3 蛋白) and FOXA1 (显示 FOXA1 蛋白) form a transcriptional complex with Ell3 to regulate IL-20 (显示 IL20 蛋白) expression in ER(+) breast cancer cells. FOXA1 (显示 FOXA1 蛋白) represses IL-20 (显示 IL20 蛋白) expression, whereas GATA3 (显示 GATA3 蛋白) and ER(alpha (显示 ESR1 蛋白)) activate it.
Selective expression of the transcription elongation factor (显示 TSFM 蛋白) ELL3 in B cells prior to ELL2 (显示 ELL2 蛋白) drives proliferation and survival
Ell3 stabilizes p53 following cisplatin treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells.
Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway
Study found that Ell3, a member of the Ell (显示 ELL 蛋白) (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II (显示 POLR2F 蛋白) elongation factors, occupies enhancers in embryonic stem cells.
The present results suggest that Ell3 promotes the differentiation of mouse embryonic stem cells by activating the expression of epithelial-mesenchymal transition-related genes and by suppressing p53 (显示 TP53 蛋白) expression.
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity).
RNA polymerase II elongation factor ELL3
, elongation factor RNA polymerase II-like 3
, RNA polymerase II elongation factor ELL3-like