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Bat Polyclonal NPY1R Primary Antibody for IHC (p) - ABIN270506
Matyal, Mahmood, Robich, Glazer, Khabbaz, Hess, Bianchi, Hagberg, Hu, Sellke: Chronic type II diabetes mellitus leads to changes in neuropeptide Y receptor expression and distribution in human myocardial tissue. in European journal of pharmacology 2011
Human Monoclonal NPY1R Primary Antibody for ELISA, WB - ABIN562042
Igura, Haider, Ahmed, Sheriff, Ashraf: Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. in Rejuvenation research 2011
the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
crystal structures of the human Y1R bound to the two selective antagonists UR-MK299 and BMS-193885 at 2.7 and 3.0 A resolution, respectively
NPY1R plays an inhibitory role in tumor growth and may be a promising therapeutic target for Hepatocellular carcinoma
expressed in to B and T lymphocytes and mast cells in infantile hemangiomas
MAPK activation by NPY Y1 receptors is an internalization-independent pathway and that this receptor can transactivate the IGFR receptor.
Report design of argininamide-type NPY1R antagonists.
NPY and its Y receptor are possible mediators of both vasoconstriction and pulmonary vascular remodelling in pulmonary hypertension
Y1R expression in visceral adipose tissue might be an indicator of increased risk of metabolic syndrome.
The influence of beta-arrestin adaptors and endocytosis mechanisms on plasma membrane diffusion and particle brightness of GFP-tagged neuropeptide Y (NPY) receptors, was investigated.
Npy1 receptor transgene overexpression is associated with modest anxiolytic-like effect on mice in the open field and elevated plus maze tests.
For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism.
neuropeptide Y1 and Y2 receptors were expressed in 33 percent of testicular tumors and Y1 on intratumoral blood vessels in 50 percent of testicular tumors
The increased expression of NPY Y1 receptor may be related to local blood flow reduction and structural changes of pelvic supporting tissue in patients with pelvic organ prolapse.
A C-terminal tyrosine-based motif is critical for the constitutive internalization of Y(1) receptors lacking the last 32 C-terminal amino acids.
results suggest that the receptor-ligand interactions have changed during evolution after Y1 and Y2 arose from a common ancestral receptor
NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
Data suggest that neuropeptide Y modulates steroid production through Y1 receptors in human adrenal H295R cells.
the NPY Y(1) receptor induces the expression of CRE containing target genes through the CaM kinase-CREB pathway
Peptide YY and neuropeptide Y exert their effects through the NPY1 receptors in human colon mucosa.
human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR); in addition, the trigeminal and superior cervical ganglia were positive for both receptors
Lower mRNA levels of neuropeptide Y receptor 1 (NPY1R) and NPY5R but not NPY or NPY2R in the central nucleus of the amygdala predicted elevated anxious temperament.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.
This study showed that the Npy1r(Y5R-/-) male mice display decreased 5-hydroxytriptamine (5-HT) positive fibres and increased baseline neural activity in orbitofrontal cortex.
the lack of Y1Rs stimulates the formation of larger multinucleated osteoclasts in vitro with reduced bone-resorbing activity.
Knockdown of the Y1 receptor induces alkaline phosphatase activity and mineralization of MC3T3-E1 cells.
NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC) mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow.
The vasoconstrictive mechanism has been identified as neuropeptide Y acting on Y1 receptors.
findings suggest that reduced Y1R expression leads to a decrease in resting vagal modulation and heart rate variability, which, in turn, may determine a reduced cardiac autonomic responsiveness to acute stress challenges.
conditional inactivation of Y1 receptors specifically in Y5 receptor containing neurons increases stress-related anxiety without affecting endocrine stress responses.
Npy1r(Y5R-/-) mice show increased anxiety-related behavior but no changes in hypothalamus-pituitary-adrenocortical axis activity or in body weight growth, independently of gender and mouse strain used as foster mothers. Also, Npy1r(Y5R-/-) mice of both genders display increased spatial reference memory in the Morris water maze test.
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
an integrated neural circuit modulates growth hormone release relative to food intake; data provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states
Regulation of neuropeptide Y Y1 receptor expression by bone morphogenetic protein 2 in C2C12 myoblasts
These findings suggest that the global absence of the Y1 receptor delays fracture healing, through impairing the early phases of fracture repair to achieve bony union.
Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity.
These studies demonstrate the pivotal, combined role of both Y1 and Y5 receptors in the mediation of food intake.
Data from knockout (KO) mice suggest roles for neuropeptide Y (Npy) and Npy1 receptors in extinction of conditioned fear. Npy1r/Npy2r double KO mice display excessive recall of conditioned fear/impaired fear extinction.
NPY Y1 receptor deficient mice lack the expression of appetitive behavior.
study demonstrates that signalling through Y1-receptors emerges as a critical pathway for the development of airway inflammation
In dentate gyrus proliferative effect of neuropeptide Y is mediated by the Y1 and not the Y2 receptor, as a Y1 ([Leu31,Pro34]), but not a Y2 (NPY3-36), receptor agonist enhanced neurogenesis.
Fluctuations in circulating levels of gonadal hormones, depending on estrous cycle, are paralleled by changes in the expression of NPY Y1 receptor in the hypothalamic nuclei involved in the control of both energy balance and reproduction.
Neuropeptide Y (NPY\; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (Herzog et al., 1992
neuropeptide Y receptor type 1
, Neuropepetide Y1 Receptor
, neuropeptide Y1 receptor
, neuropeptide Y Y1 receptor
, G-protein coupled receptor
, neuropeptide Y receptor Y1
, Y1 neuropeptide Y receptor
, Neuropeptide Y receptor type 1
, gastric Y1 receptor
, neuropeptide Y receptor type 1-like
, NPY-1 receptor
, neuropeptide Y receptor subtype
, neuropeptide Y receptor Y1, NPY/PYY receptor Y1