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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
Adenocarcinomas showed significantly higher staining scores of both VEGF (显示 VEGFA 蛋白) and alphaSMA than squamous cell carcinomas did. In 42 cases of high CD31 (显示 HBA1 蛋白) score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels
connective tissue disease including ACTA2 mutations should be considered for aortic dissection in young adult patients.
cellular defects due to the ACTA2 mutation in both aortic smooth muscle cells and adventitial fibroblasts may contribute to development of thoracic aortic aneurysms and dissections and proliferative occlusive vascular disease
our results seemed to justify the conclusion that ACTA2 did not play a significant role in the pathogenesis of BAV aortopathy.
In patients with MYH11 (显示 MYH11 蛋白) or ACTA2 variants, the effect of intronic variants on splicing was demonstrated on the mRNA level in the induced smooth muscle cell (SMC (显示 DYM 蛋白)), allowing classification into pathogenic or nonpathogenic variants.
We present a young woman whose ACTA2 mutation was ascertained during pregnancy because of her father's history of dissecting aneurysms. She was delivered at full term by cesarean section and subsequently had severe uterine hemorrhage due to uterine atony. Targeted analysis of the patient's ACTA2 gene revealed she had inherited the N117S variant from her father.
During transition from the pluripotent stage towards the neural developmental stage, ACTA2 is differentially expressed in bipolar patient derived cells compared to control derived cells.
Two unrelated patients with the heterozygous R189H mutation in ACTA2 and complex congenital heart defects expands the cardiac phenotype of multisystemic smooth muscle dysfunction syndrome.
Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (显示 HBA1 蛋白) and VE-cadherin (显示 CDH5 蛋白), and a significant increase in that of alpha-SMA (显示 SMN1 蛋白) and collagen I.
ACTA2 is the isoform of contractile protein (显示 TNNT2 蛋白) alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4
These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGFbeta1 (显示 TGFB1 蛋白)-induced epithelial-mesenchymal transition via alphaSMA expression induction.
The level of alpha-SMA (显示 SMN1 蛋白) expression by intramuscular fibrogenic cells does not correlate positively with the level of collagen gene expression or the severity of skeletal muscle fibrosis in the mdx5cv mice. alpha-SMA (显示 SMN1 蛋白) is not a functional marker of fibrogenic cells in skeletal muscle fibrosis associated with muscular dystrophy
Data suggest that membrane-proximal signaling complexes constrained by AKAP220 impact the actin barrier dynamics and AQP2 (显示 AQP2 蛋白) trafficking to ensure water homeostasis.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (显示 SMN1 蛋白), and COL1a1 (显示 COL1A1 蛋白) expression in a liver fibrosis disease model.
Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB (显示 NFKB1 蛋白) signaling and increases AngII receptor type I a expression.
The expression levels of alpha-smooth muscle actin (显示 ACTG2 蛋白) (alpha-SMA (显示 SMN1 蛋白), a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers.
this study identifies Rac1 as a downstream target for SMA (显示 SMN1 蛋白) to inhibit smooth muscle cell proliferation and migration.
the coordinated up-regulations of desmin (显示 DES 蛋白) and alpha- actinin (显示 ACTN1 蛋白) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.
site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta (显示 PURB 蛋白) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (显示 PURB 蛋白) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (显示 FXYD5 蛋白)...
Alpha-smooth muscle actin (显示 ACTG2 蛋白) protein (显示 ACTR3 蛋白) and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model.
TnT has a previously unrecognized role in forming the inactive state of regulated actin.
The terminal pointed end subunit is tilted (显示 OTOP1 蛋白) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.
There was no significant change in the expression of TGF-beta(2 (显示 TGFB2 蛋白)) and alpha-SMA (显示 SMN1 蛋白) after laser-assisted intrastromal scanning.
The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.
The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, alpha smooth muscle actin
, actin, alpha 2, smooth muscle, aorta
, actin alpha cardiac 1
, actin, aortic smooth muscle
, vascular smooth muscle alpha-actin
, alpha-smooth muscle actin
, actin, aortic smooth muscle-like
, alpha-cardiac actin
, cell growth-inhibiting gene 46 protein
, actin, alpha, vascular smooth muscle
, alpha actin 2
, smooth muscle alpha-actin
, alpha actin