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抗Mouse (Murine) 抗体:
findings show alphaRYR & betaRYR use divergent mechanisms to generate molecular variations; alternative splicing generates variants of alphaRYR, whereas presence of SNPs may change the secondary mRNA structure of betaRYR.
a genome-wide linkage scan and regional association fine-mapping identified variants in the RYR3 gene as a quantitative trail locus for plasma adiponectin levels in Chinese population
Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Data show that the common variant single-nucleotide polymorphism rs2229116 of the ryanodine receptor 3 gene (RYR3) was significantly associated with carotid intima-media thickness (cIMT).
SNPs within the RYR3 region were associated with subclinical atherosclerosis among HIV-infected women. Allelic heterogeneity observed across the three races suggests that the contribution of the RYR3 gene to CCA cIMT is complex.
rs877087 and rs2229116 of RYR3 gene are associated with atherosclerosis severity in Japanese.
a genetic interaction between the RYR3 and CACNA1C genes explained variance in amyloid deposition above and beyond other major known risk factors for late-onset Alzheimer's disease
The findings reported here for the case-only analysis of the antihypertensive pharmacogenetic effect of RYR3 among 3058 CHD cases .
the rectified RyR3 channel in open conformation may be regulated in situ by two cytosolic activating Ca(2+) sites
The current study suggests that the functional variant (rs1044129) in the miR-367 binding site of RYR3 may be a potential marker for prognosis in patients following curative surgery for colorectal cancer
RyR1, RyR2, and RyR3 transcripts were detected in human T cells, RyR1/2 transcript levels increased, whereas those of RyR3 decreased after T cell activation.
RYR3 gene polymorphisms are associated with common carotid intima-media thickness in HIV-infected white males.
Alterations in RyR3 expression at early disease stages may reflect the onset of pathologic mechanisms leading to later neurodegeneration.
The study provides biochemical evidence of the interaction between FKBP12 and RYR1, RYR3 and IP3R.
RyR expressed in epidermal keratinocytes is associated with both differentiation of keratinocytes and epidermal barrier homeostasis.
A putative binding site for microRNA-367 exists in the 3'UTR of RYR3, and a genetic variant, rs1044129 A-->G, is present in this binding region.
smooth muscle RYR3 may function as a suppressor of RyR2-mediated Ca2+ release by forming heteromeric channels with a decreased sensitivity to activation by luminal Ca2+
essential in the sustained Ca(2+) response in T cells
smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor)
RNase protection assay and in situ hybridization revealed that RYR2 mRNA expresses widely in the heart including the SA-node, while RYR3 mRNA expression is limited to the SA-node and to the right atrium.
the central binding site for the 12 kDa FK506-binding protein of type-3 ryanodine receptor, encompassing the critical valine proline motif, plays a crucial role in the modulation of the Ca2+ release properties
Deletion of RyanR3 increased hippocampal neuronal network excitability and accelerated Alzheimer disease pathology.
Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR.
knockdown of RyR1-3 expression in wild-type hippocampal neurons to levels comparable with the RyR protein reduction in presenilin-deficient hippocampal neurons mimics the defects exhibited in calcium homeostasis and presynaptic function
Silencing of RyR3 expression in 3T3-L1 preadipocytes resulted in up-regulated adiponectin promoter activity, enhanced adiponectin mRNA expression, and more adiponectin protein secreted into the medium.
Requirement of functional ryanodine receptor type 3 for astrocyte migration
Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3.
ryanodine receptor-mediated calcium-induced calcium release is involved in the regulation of CRH-induced ACTH release.
Duodenal myocytes expressed both type 2 and type 3 ryanodine receptors and were unable to produce calcium sparks.
as the stimulation of muscarinic receptor in the airway smooth muscle increases, RyR1 and/or RyR3 also mediate the calcium response and thus bronchoconstriction
The short isoform of RYR3 controls calcium release through RYR2 in native smooth muscle cells.
relative levels of expression of RyR1 and RyR3 isoforms in developing mouse hindlimb and diaphragm muscles were determined
Physiologically voltage-controlled Ca(2+) sparks thus require a voltage sensor, a master junctional RyR1 channel that provides trigger Ca(2+), and a slave parajunctional RyR3 cohort
Kinetic analysis reveals that systemic ablation of RyR3 results in significant changes to the initiation, duration and amplitude of individual Ca2+ sparks in muscle fibers.
There is a specialized function of RyR3 in CA1 pyramidal cells in triggering slow afterhyperpolarization currents due to their localization in the apical dendrite.
physiological regulation of RYR3 alternative splicing may play an essential role at the end of pregnancy
RyR3 is a very potent source of voltage-independent Ca2+ release activity in adult mouse skeletal muscle fibres.
Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules
A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated
Report heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene.
ryanodine receptor type 3
, brain ryanodine receptor
, ryanodine receptor 3
, Brain ryanodine receptor-calcium release channel
, Brain-type ryanodine receptor
, Type 3 ryanodine receptor
, brain ryanodine receptor-calcium release channel
, brain-type ryanodine receptor
, type 3 ryanodine receptor
, calcium release channel