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the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo.
study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6
genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied.
Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities.
Our results suggest that HA117 is a strong multidrug resistance gene.
This suggests that HA117 might be an important resistance gene in pediatric solid tumors.
No significant association between SNPs of RGS6 and central adiposity has been found.
reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker
these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target.
we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes.
genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype
RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins
interacts with SCG10 and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of this protein
Role of the RGS domain in stress-induced trafficking of RGS6 protein
RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants
RGS6 is the first member of the RGS protein family shown to interact with proteins involved in transcriptional regulation.
RGS6 and oxidized CaMKIIdelta together function as novel critical upstream modulators of Notch signaling required for normal cardiovascular development and embryo survival.
Data show that RGS6 loss impairs p53 activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.
The genetic loss of Rgs6 is associated with three phenotypes each individually associated with midbrain dopaminergic neuron neuron degeneration.
propose that inhibition of RGS6 might represent a viable means to reduce alcohol cravings and withdrawal in human patients, while simultaneously protecting the heart and liver from further damage upon relapse
RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis
Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.
Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis.
RGS6-Gbeta5, but not RGS4, is the primary RGS modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.
Spontaneous tumor formation was also seen in old female RGS6(-/-) but not in wild-type mice.
results identify RGS6 as an essential mediator of the pathogenic responses to doxorubicin in heart, and they argue that RGS6 inhibition offers a rational means to circumvent doxorubicin cardiotoxicity in human patients with cancer
establish RGS6 as a key component of GABA(B)R signaling
Regulator of G-protein signaling 6 (RGS6) is a previously unrecognized, but essential, negative regulator of parasympathetic activation in heart.
The cardiac complex (regulator of G-protein signaling 6) RGS6/Gss5 modulates the timing of parasympathetic influence on atrial myocytes and heart rate.
Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults.
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.
regulator of G-protein signaling 6
, regulator of G-protein signalling 6
, regulator of G-protein signaling 6-like
, GTPase activating protein