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Significant correlation between severities of skin manifestations with GSTO1 polymorphism status in arsenic-exposed population of India.
GSTO1*C is linked to the pre-stage of Alzheimer's disease; rs4925 could be a genetic marker for cognitive impairment
This study demonstrated that Distribution of the GSTO1 alleles and genotypes was nearly equal between the control group and SCA2 (显示 LY6E 蛋白) patients. GSTO1 genotypes were not associated to clinical markers in SCA2 (显示 LY6E 蛋白) patients.
GSTO1 genetic polymorphisms are associated with the progression of HBV infection.
GSTP1 (显示 GSTP1 蛋白) and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity.
No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 (显示 GSTO2 蛋白) N142D polymorphisms.
The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene.
Our results indicate that GSTO1*C/GSTO2 (显示 GSTO2 蛋白)*G haplotype is associated with increased risk of TCC (显示 SFXN1 蛋白). The modifying effect of GSTO2 (显示 GSTO2 蛋白)*G/G genotype on individual susceptibility to TCC (显示 SFXN1 蛋白) is more pronounced, when associated with smoking.
This meta-analysis demonstrates that GSTO2 (显示 GSTO2 蛋白) polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.
Our study is the first to show that the frequency of GSTO1 A140D gene polymorphism in the Turkish population is similar to other Caucasian populations and that this polymorphism is not associated with susceptibility to NSCLC.
Data indicate that GSTO1-1 is required for LPS (显示 TLR4 蛋白)-mediated signalling in macrophages and that it acts early in the LPS-TLR4 (显示 TLR4 蛋白) pro-inflammatory pathway.
shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 (显示 NOX3 蛋白) and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
Genes encoding the antioxidants GPX2 (显示 GPX2 蛋白) and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.
glutathione S-transferase omega-1
, glutathione transferase omega-1
, glutathione S-transferase omega 1
, glutathione-S-transferase omega 1
, glutathione S-transferase O1
, GSTO 1-1
, MMA(V) reductase
, S-(Phenacyl)glutathione reductase
, glutathione S-transferase omega 1-1
, glutathione-dependent dehydroascorbate reductase
, monomethylarsonic acid reductase
, glutathione-S-transferase like
, Glutathione transferase omega 1 (GSTO 1-1) (p28)
, glutathione S-transferase like