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rs13093 in the promoter region of GNG5 may be associated with an increased risk of essential hypertension in the Polish population.
Targeted disruption of the mouse Gng5 gene encoding the gamma5 subtype produces embryonic lethality associated with severe head and heart defects.
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987
G protein gamma-5 subunit
, guanine nucleotide binding protein (G protein), gamma 5 subunit
, guanine nucleotide binding protein gamma 5
, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5