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expression of GNG11 induced the generation of reactive oxygen species (ROS (显示 ROS1 蛋白)) and abnormal nuclear morphology in SUSM-1 cells but not in HeLa cells
Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues.
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas.
G protein gamma-11 subunit
, guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit
, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
, guanine nucleotide binding protein gamma subunit 11