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rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes.
ANXA1 and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression.
Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells.
Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas.
caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum
The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD.
Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis.
Caldesmon expression inhibits cancer cell migration and invasiveness.
Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves
Data found phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium.
Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases.
Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers.
An involvement of caldesmon in the susceptibility to diabetic nephropathy in type 1 diabetes, independently from environmental glucose levels.
h-caldesmon is useful in distinguishing atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma
Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling
Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates.
The effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin, was studied.
Specific but variable expression of h-caldesmon in leiomyosarcomas
Motifs of the caldesmon family.
results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes
Silencing of Sox4 decreased not only CaD protein synthesis but also myoblast fusion in C2C12 cells and myofibril formation in mouse embryonic muscle. Overexpression of CaD in Sox4-silenced C2C12 cells rescued the differentiation process.
Caldesmon-deficient mouse arterial muscles relax more slowly than wild-type tissues.
distribution of the actin-binding protein caldesmon in spleen and lymph nodes of mice and rats
Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells
This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 can act as an anti-motility/invasion/metastasis agent.
Acrylodan-labeled tropomyosin fluorescence responses to rapid myosin subfragment S1-ATP detachment in the presence of caldesmon are similar to those observed in the presence of troponin.
Effect of long-term partial bladder outlet obstruction on caldesmon isoforms and their correlation with contractile function are reported.
Use short interfering RNA technology to decrease the levels of the smooth muscle-specific isoform of caldesmon in intact vascular smooth muscle tissue to determine what role(s) caldesmon has in smooth muscle regulation.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
, non-muscle caldesmon
, caldesmon, smooth muscle
, caldesmon 1
, smooth muscle caldesmon