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PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.
acyl-CoA thioesterase 7
, cytosolic acyl coenzyme A thioester hydrolase
, cytosolic acyl coenzyme A thioester hydrolase-like
, brain acyl-CoA hydrolase
, acyl-CoA thioesterase 2
, acyl-CoA thioesterase, long chain
, brain acyl CoA hydrolase
, long chain acyl-CoA thioester hydrolase
, 50-kDa brain acyl-CoA hydrolase