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Study demonstrated that Psme3/Psme4 (显示 PSME4 抗体) double KO (dKO) male mice are completely infertile and showed the up-regulation of several proteins involved in oxidative stress response in dKO sperms. These results suggest the important role of PA28gamma and PA200 (显示 PSME4 抗体) in male fertility.
Findings reveal a novel regulatory pathway in which the REGgamma-proteasome controls the steady-state level of GSK3beta protein.
PSME3 is a target gene of NF-kappaB (显示 NFKB1 抗体) during bacterial infections. PSME3 activates NF-kappaB (显示 NFKB1 抗体) by degrading KLF2 (显示 KLF2 抗体).
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
REGgamma acts in skin tumorigenesis mediating MAPK/p38 (显示 MAPK1 抗体) activation of the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway.
In a p53 (显示 TP53 抗体)-dominated cellular context, pro-apoptotic signaling might be overcome by PA28gamma-mediated caspase (显示 CASP3 抗体) inhibition.
Data suggest levels of gene expression of both Psme3 (proteasome activator subunit 3) and Dusp3 (dual specificity phosphatase 3 (显示 DUSP3 抗体)) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model.
PKA turnover by the REGgamma-proteasome modulates FoxO1 (显示 FOXO1 抗体) cellular activity and VEGF (显示 VEGFA 抗体)-induced angiogenesis.
REGgamma binds to SirT1 (显示 SIRT1 抗体), promotes its Ub-independent degradation, and inhibits its activity to deacetylate autophagy-related proteins, thereby inhibiting autophagy under normal conditions.
REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53 (显示 TP53 抗体). Antibody array analysis identified CK1delta as a direct target of REGgamma.
that Proteasome activator subunit 3 induces epithelial-mesenchymal transition with inducing the expression of CSC markers and influencing the tumor immune microenvironment in breast cancer
PSME3 plays an oncogenic role in pancreatic cancer by inhibiting c-Myc (显示 MYC 抗体) degradation to promote glycolysis.
Study demonstrated that the gene therapy with proteasome activator, PA28gamma can improve ubiquitin-proteasome system function as well as behavioral abnormalities in Huntington's disease model mice
Surrogate Prognostic Biomarkers in OSCC: The Paradigm of PA28gamma Overexpression.
PA28gamma in OSCC tumor tissues were significantly high expression than those in normal tissues.
Results show molecular cloning of a novel transcript variant encoding a truncated form of PA28G likely involved in cell cycle regulation and apoptosis.
Our results suggest that the high expression of REGgamma might predict metastasis and poor prognosis in breast cancer.
Increased PA28gamma sera levels were prognostic of disease activity in rheumatoid arthritis.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.
11S regulator complex subunit gamma
, activator of multicatalytic protease subunit 3
, ki nuclear autoantigen
, proteaseome (prosome, macropain) 28 subunit, 3
, proteasome activator 28 subunit gamma
, proteasome activator complex subunit 3
, 11S regulator complex gamma subunit
, Ki antigen
, Ki nuclear autoantigen
, PA28 gamma variant 5
, proteasome activator 28-gamma
, proteasome activator subunit 3