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Yeast (Saccharomyces cerevisiae) Polyclonal PSMD8 Primary Antibody for IP, WB - ABIN2452112
Takeuchi, Toh-e et al.: Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic ... in Molecular & general genetics : MGG 1999
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Human Polyclonal PSMD8 Primary Antibody for ICC, IP - ABIN1742386
Takamori, Holt, Stenius, Lemke, Grønborg, Riedel, Urlaub, Schenck, Brügger, Ringler, Müller, Rammner, Gräter, Hub, De Groot, Mieskes, Moriyama, Klingauf, Grubmüller, Heuser, Wieland, Jahn: Molecular anatomy of a trafficking organelle. in Cell 2006
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These findings support the hypothesis that neurodegenerative disorders result primarily from a generic cell dysfunction caused by early misfolded species in the aggregation process.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
26S proteasome non-ATPase regulatory subunit 8
, 26S proteasome regulatory subunit RPN12
, 26S proteasome regulatory subunit S14
, 26S proteasome regulatory subunit p31
, proteasome 26S non-ATPase subunit 8 b
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 b
, proteasome 26S non-ATPase subunit 8
, proteasome 26S subunit, non-ATPase, 8
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 a
, proteasome 26S non-ATPase subunit 8 a
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 8