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autoinflammation-associated H443P nlrc4 mutant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD but independent of Ser(533) phosphorylation.
results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.
Our data suggest that PSMC5 facilitates the damaging effects of radiation in radiation-responsive H460 cancer cells and therefore may serve as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients.
XopJ has protease activity to specifically degrade RPT6.
TRIP-1 regulates fibroblast acquisition of phenotype and function associated with myofibroblasts.
gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity
Rpt6 interacts directly with CKIP-1 and promotes the turnover of Smurf1.
Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO.
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity
Findings show that Sug1 is crucial for regulating histone H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA promoters.
SUG1 has a role in ubiquitin/proteasome-mediated degradation of estrogen receptors
Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo.
p45 plays an important role in regulating ataxin-3 degradation by the proteasome.
cyclic AMP-dependent protein kinase regulates proteasome function through phosphorylation of Rpt6
These data demonstrate that both 19S and 20S subunits of the 26S proteasome play specific and critical roles in regulating CIITA activity and MHC class II transcription.
The current study strongly implicates the 19S ATPase Sug1 in modifying histones to initiate major histocompatibility complex class II transcription and provides novel insights into the role of the proteasome in the regulation of mammalian transcription.
SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
26S protease regulatory subunit 8
, 26S proteasome AAA-ATPase subunit RPT6
, proteasome 26S subunit ATPase 5
, proteasome subunit p45
, MSUG1 protein
, Tat-binding protein homolog 10
, proteasome 26S ATPase subunit 5
, thyroid hormone receptor-interacting protein 1
, thyroid receptor interactor 1
, for proteasomal ATPase (SUG1)
, peptidase (prosome, macropain) 26S subunit, ATPase 5
, protease (prosome, macropain) 26S subunit, ATPase 5
, proteasomal ATPase (SUG1)
, proteasome p45/SUG
, 26S protease subunit
, TAT-binding protein homolog 10
, SUG1 homolog