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Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5 (显示 PSMB5 蛋白), PSMB6 (显示 PSMB6 蛋白), PSMB8, PSMB9 (显示 PSMB9 蛋白), and PSMB10 (显示 PSMB10 蛋白).
In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered.
The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1 (显示 CDKN1B 蛋白).
The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.
Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 (显示 CD68 蛋白) expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab.
PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.
Expression of 26S proteasome (显示 Psmd4 蛋白) beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3).
data defined a unique motif of BCL-3 (显示 BCL3 蛋白) that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.
proteasome beta 1 subunit
, proteasome subunit beta type-1
, proteasome subunit beta type 1
, hypothetical protein
, component C5 of proteasome
, macropain subunit C5
, multicatalytic endopeptidase complex subunit C5
, proteasome beta-subunit C5
, proteasome component C5
, proteasome gamma chain
, proteasome subunit C5
, proteasome subunit RC5
, proteasome subunit HC5
, proteasome subunit beta-type
, TATA-box binding protein