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抗Mouse (Murine) MAX 抗体:
抗Human MAX 抗体:
抗Rat (Rattus) MAX 抗体:
Studies suggest that inducible MYC Associated Factor X (MAX) knockout embryonic stem cells (ESCs (显示 NR2E3 抗体)) provide an excellent platform for exploring the molecular mechanisms of meiosis initiation.
Myc (显示 MYC 抗体) represses C/EBPdelta (显示 CEBPD 抗体) expression by associating with the C/EBPdelta (显示 CEBPD 抗体) proximal promoter as a transient component of a repressive complex that includes Max and Miz1 (显示 PIAS2 抗体)
The switch from Mnt-Max to Myc (显示 MYC 抗体)-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 (显示 TP53 抗体) and cyclin D1 (显示 CCND1 抗体) expression and contributes to apoptosis.
the c-Myc (显示 MYC 抗体)-Max complex exerts its transcriptional regulatory role and hnRNP U (显示 HNRNPU 抗体) may be a coactivator of this transcriptional activator complex.
To our knowledge, this is the first report of an association between dysregulation of the MAX-MYC (显示 MYC 抗体) network in the brain and a behavior, suggesting a novel approach for exploiting the neuroplasticity associated with depression
Sequence-specific DNA binding by MYC (显示 MYC 抗体)/MAX to low-affinity non-E-box motifs
The SDHA (显示 SDHA 抗体), TMEM127 (显示 TMEM127 抗体), MAX, and SDHAF2 (显示 Sdhaf2 抗体) genes contribute to hereditary pheochromocytoma and paraganglioma.
These results suggest that the wild type Max homodimer is important for attenuating the binding of c-Myc (显示 MYC 抗体) to specific and non-specific DNA, whereas alternative splicing (e.g. DeltaMax) is unable to do so. Conversely, the splicing of Max into DeltaMax could provoke an increase in overall chromatin bound c-Myc (显示 MYC 抗体).
The mechanism of inhibition of c-Myc (显示 MYC 抗体) transcriptional activity by Miz-1 (显示 ZBTB17 抗体) that binds c-Myc (显示 MYC 抗体) while competing for binding with Max has been described.
The introduction of wild-type MAX cDNA into PC12 cells significantly decreased MYC's ability to bind to canonical E-boxes, while pathogenic MAX proteins were not able to fully repress MYC (显示 MYC 抗体) activity. Further clinical and molecular evaluation of variant carriers corroborated the results obtained with the functional assessment.
Celastrol and some of its quinone methidecontaining analogs directly inhibit c-Myc (显示 MYC 抗体)-Max heterodimers in tumor cells.
We confirmed that these dimeric inhibitors directly bind to Myc (显示 MYC 抗体) blocking its interaction with Max and affect transcription of MYC (显示 MYC 抗体) dependent genes.
MYC (显示 MYC 抗体) is part of a network of bHLHLZ proteins centered on the MYC (显示 MYC 抗体) heterodimeric partner MAX and its counterpart, the MAX-like protein MLX (显示 MLX 抗体).
Myc (显示 MYC 抗体) and its obligate heterodimeric partner, Max, are integral to the coordinated recruitment and post-translational modification of components of the core transcriptional machinery.
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
myc-associated factor X
, myc-binding novel HLH/LZ protein
, protein max
, protein myn
, class D basic helix-loop-helix protein 4