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抗Human CDC7 抗体:
抗Rat (Rattus) CDC7 抗体:
抗Mouse (Murine) CDC7 抗体:
Human Polyclonal CDC7 Primary Antibody for WB - ABIN1882165
Sato, Arai, Masai: Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. in The EMBO journal 1997
Show all 4 Pubmed References
Human Monoclonal CDC7 Primary Antibody for ICC, IF - ABIN265783
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. in Science signaling 2013
Human Polyclonal CDC7 Primary Antibody for IHC (p) - ABIN4296982
Kitamura, Fukatsu, Kakusho, Cho, Taniyama, Yamazaki, Toh, Yanagi, Arai, Chang, Masai: Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. in The Journal of biological chemistry 2011
Results suggest a new role of Claspin (显示 CLSPN 抗体) in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins.
Increased Cdc7-dependent replication initiation is a hallmark of p53 (显示 TP53 抗体) gain-of function mutations in lung adenocarcinoma.
Both CDC7 and DBF4 (显示 DBF4 抗体) promoters bind E2F (显示 E2F1 抗体), suggesting that increased E2F (显示 E2F1 抗体) activity in RB1 (显示 RB1 抗体) mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies.
p53 (显示 TP53 抗体)-dependent control of CDC7 levels is essential for blocking G1/S cell-cycle transition upon genotoxic stress.
we propose that phosphorylation of TOP2A (显示 TOP2A 抗体) by CDC7/DBF4 (显示 DBF4 抗体) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (显示 TOP2A 抗体) function could be relevant to prevent premature separation of centromeric DNA.
The data support a model where Cdc7 (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 and PP1a (显示 PPP1CA 抗体)/Cdk1 (显示 CDK1 抗体) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (显示 TGFBR3 抗体)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (显示 MLXIP 抗体)-630 promoted apoptosis by downregulation of CDC7.
The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A (显示 PPP2R4 抗体)-dependent dephosphorylation.
Cdc7 physically and functionally interacts with Nkx2.5 (显示 NKX2-5 抗体) to regulate Myocd (显示 MYOCD 抗体) promoter activity
Cdc7 mediates SMC (显示 DYM 抗体) differentiation through a mechanism distinct from cell proliferation.
MCM4 (显示 MCM4 抗体) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (显示 CDC45 抗体) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1