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抗Human RHOA 抗体:
Results indicate that miR (显示 MLXIP 抗体)-126 acts as a tumor suppressor by inactivating RhoA signaling via CXCR4 (显示 CXCR4 抗体) in colon cancer.
RhoA expression patterns in circulating leucocytes is a biomarker for the breast cancer risk assessment.
Receptor tyrosine kinase (显示 RET 抗体) activation of RhoA is mediated by AKT (显示 AKT1 抗体) phosphorylation of DLC1 (显示 DYNLL1 抗体).
DOCK7 (显示 DOCK7 抗体) controls neuronal growth via a Rac (显示 AKT1 抗体)-dependent pathway, likely by modulating microtubule networks while also regulating F-actin remodeling at the cell rear to promote somal translocation via a previously unrecognized myosin phosphatase-RhoA-interacting protein-dependent pathway.
The ability of enhanced GNA13 (显示 GNA13 抗体) signaling to suppress KLK gene expression appears at least in part due to the ability of enhanced GNA13 (显示 GNA13 抗体) signaling to negatively impact Rho/ROCK-signaling.
OB-Rb (显示 LEPR 抗体), RhoA/ROCK, PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体), JAK (显示 JAK3 抗体)/STAT (显示 STAT1 抗体) pathways and NF-kB activation are involved in leptin (显示 LEP 抗体)-induced upA (显示 PRAP1 抗体) expression.
study strongly supported the contribution of the genes ITGA2B, GSN and RHOA and the two pathways "regulation of actin cytoskeleton" and "leukocyte transendothelial migration" to osteoporosis risk.
Suggest RHOA mutations useful for diagnosing cutaneous localizations of angioimmunoblastic T-cell lymphomas.
TET2 (显示 TET2 抗体) and RhoA mutations cooperatively disrupt T cell homeostasis
Genetic variant in RhoA gene is associated with progression of prostate cancer.
Codepletion of the actomyosin regulator RhoA and Afadin (显示 MLLT4 抗体) results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2 (显示 VAV2 抗体).
These results reveal a novel signaling network, the Sema4D (显示 SEMA4D 抗体)-RhoA-Akt (显示 AKT1 抗体) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
RhoA deficiency could disrupt podocyte cytoskeleton and induce podocyte apoptosis by inhibiting YAP/dendrin signal.
These results suggested that, in addition to inhibiting Noggin (显示 NOG 抗体) transcription, RhoA activity in wild-type murine embryonic stem cells also prevented neural differentiation by limiting Noggin (显示 NOG 抗体) secretion.
Rho attenuates the interaction between Amot (显示 AMOT 抗体) and Nf2 (显示 NF2 抗体) by binding to the coiled-coil domain of Amot (显示 AMOT 抗体).
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (显示 ROR2 抗体), which influenced Ras Homology Family Member A (显示 CXCL14 抗体) (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (显示 ROCK1 抗体)) activity downstream of Dishevelled-2 (Dvl2 (显示 DVL2 抗体)).
Active Rho-kinase (显示 ROCK2 抗体) diffuses to growing other immature neurites and inhibits their outgrowth to ensure single axon formation.
Data indicate that oxidative stress in diabetes causes a decrease in miR (显示 MLXIP 抗体)-133a expression leading to an increase in RhoA/Rho kinase (显示 ROCK2 抗体) pathway and muscle contraction.
Downregulation of Cul3 (显示 CUL3 抗体) led to a marked increase in RhoA protein expression after 6 days of adipocytes differentiation, suggesting that Cul3 (显示 CUL3 抗体) is involved in the regulation of RhoA stability.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1 (显示 CASZ1 抗体)/Egfl7 (显示 EGFL7 抗体)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (显示 KAZ 抗体) interacts with ARVCF (显示 ARVCF 抗体)-catenin, spectrin and p190B (显示 ARHGAP5 抗体) RhoGAP (显示 ARHGAP1 抗体), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (显示 SRC 抗体)/FAK (显示 PTK2 抗体) activation in response to shear stress.
the Lbc (显示 AKAP13 抗体)/alpha-catulin (显示 CTNNAL1 抗体) axis participates in 5-HT (显示 DDC 抗体)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (显示 PTK2 抗体)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (显示 CA2 抗体)+)](i), as well as the voltage-dependent Ca(2 (显示 CA2 抗体)+) currents
the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (显示 PTK2 抗体) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (显示 TNF 抗体) stimulates Rac (显示 AKT1 抗体), ADAM17/TACE (显示 ADAM17 抗体), and RhoA through the guanine nucleotide exchange factor (显示 ARHGEF12 抗体) (GEF)-H1 (显示 ARHGEF2 抗体).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (显示 LIMK1 抗体) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (显示 TGFB1 抗体) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (显示 ROCK1 抗体) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin (显示 F2 抗体) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R 抗体), RhoA, and myocardin (显示 MYOCD 抗体).
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A