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抗Mouse (Murine) CLASP2 抗体:
抗Human CLASP2 抗体:
抗Rat (Rattus) CLASP2 抗体:
Human Polyclonal CLASP2 Primary Antibody for ICC, IF - ABIN439355
Langlais, Dillon, Mengos, Baluch, Ardebili, Miranda, Xie, Heckmann, Liu, Mandarino: Identification of a role for CLASP2 in insulin action. in The Journal of biological chemistry 2012
Show all 2 Pubmed References
The novel protein SOGA1 (显示 SOGA1 抗体) was confirmed to colocalize with a microtubule-associated protein (显示 SPAG5 抗体) CLASP2 and with tubulin (显示 TUBB 抗体), which identifies SOGA1 (显示 SOGA1 抗体) as a new microtubule-associated protein (显示 SPAG5 抗体).
data reveal that CLASP2 is an essential Reelin (显示 RELN 抗体) effector orchestrating cytoskeleton dynamics during brain development.
These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
A transport system, organized by agrin (显示 AGRN 抗体) through PI3 kinase (显示 PIK3CA 抗体), GSK3beta, CLASP2, and LL5beta (显示 PHLDB2 抗体), for precise delivery of acetylcholine receptor (显示 CHRNB1 抗体) vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
the functional relationship between Abl (显示 ABL1 抗体) and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120 (显示 CTNND1 抗体)) in primary basal mouse keratinocytes.
CLASP2 is required for the proper attachment of fibroblasts, HSC (显示 FUT1 抗体)-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
CLASP2 directs the delivery of GLUT4 (显示 SLC2A4 抗体) to cell cortex landing zones important for insulin (显示 INS 抗体) action
Short-hairpin RNA-mediated CLASP2 knockdown in mouse neurons decreases axon & dendritic length. It is involved in cytoskeleton-related neuronal polarity & interplay between microtubule stabilization & synapse formation & activity.
the cascade linking agrin (显示 AGRN 抗体) to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype
CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin (显示 CDH1 抗体) mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor.
Prickle1 (显示 PRICKLE1 抗体) localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 (显示 PRICKLE1 抗体) to regulate migration, to bind to CLASPs and LL5beta (显示 PHLDB2 抗体), and to promote microtubule targeting of focal adhesions.
this study shows that GSK3-mediated phosphorylation of CLASP2alpha largely abolishes CLASP2alpha-microtubule association in metaphase thus contributing to correct chromosome dynamics
PAR3 (显示 F2RL2 抗体) and aPKC control the organization of the Golgi through CLASP2 phosphorylation.
GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor (显示 CHRNA1 抗体) cluster size through the regulated capture and release of microtubule plus-ends.
Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM (显示 MMRN1 抗体), establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.
Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 (显示 ARPP21 抗体) and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability.
Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.
The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).
CLIP-associating protein 2
, cytoplasmic linker-associated protein 2
, cytoplasmic linker associated protein 2
, CLIP-associating protein CLASP2
, multiple asters (Mast)-like homolog 2
, protein Orbit homolog 2
, CLIP associating protein 2