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These are the first data that mechanistically link eIF2Bepsilon abundance to skeletal myofibre hypertrophy.
A point mutation in translation initiation factor eIF2B leads to Vanishing White Matter disease.
Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation.
Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs).
Oligodendrocytes with truncated or deletion mutants eIF2B showed less tolerable to endoplasmic reticulum stress
These data emphasize the importance of eIF2Balpha in mediating the eIF2 kinase translation-inhibitory activity and may provide insight into the complex nature of vesiculovirus oncolysis.
mutational analysis of the eIF2B genes of patients with an antenatal- or early-infantile-onset encephalopathy and an early demise
Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity.
analysis of novel mutations in patients with eIF2B-related disorders
Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon)
The authors suspected VWM and sequenced the genes EIF2B1-5, which revealed one heterozygous mutation in EIF2B4.
Crystal structure of the alpha subunit of human translation initiation factor 2B.
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
translation initiation factor eIF-2B subunit alpha
, Translation initiation factor eIF-2B subunit alpha
, translation initiation factor eif-2b subunit alpha
, eIF-2B GDP-GTP exchange factor subunit alpha
, eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)
, GTP-exchange protein