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Our study suggested markers in BHMT/BHMT2 (显示 BHMT2 蛋白) and DMGDH (显示 DMGDH 蛋白) might affect the risk of NSCL (显示 NHLH1 蛋白)/P through pairwise interaction.
BHMT (rs3733890) polymorphism showed no association with ALL. Hence this investigation needs further evaluation in larger sample size and effect of other SNPs, CNVs and miRNA's is required to elucidate the role of BHMT gene in ALL development.
In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
It was concluded that during pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.
low BHMT expression is correlated with aggressive malignant phenotype of HCC (显示 FAM126A 蛋白). Our data indicate that BHMT may serve as a novel prognostic marker for HCC (显示 FAM126A 蛋白).
The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT.
Multiple SNPs in BHMT and BHMT2 (显示 BHMT2 蛋白) were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements.
Data suggest BHMT is activated by binding of potassium ions; role of potassium ions in BHMT appears to be structural; potassium ions facilitate specific binding of substrate homocysteine (rather than substrate betaine) to active site of the enzyme.
Study suggests BHMT holds considerable potential as a blood biomarker for acute liver injury.
Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy.
These findings indicate that greater synthesis of phosphatidylcholine (显示 SGMS1 蛋白) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
Data indicate that improved Sp1 transcription factor (Sp1) and betaine homocysteine-S-methyltransferase (BHMT) expression are involved in the effects of zinc on oxidative stress.
Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging volume, as well as impaired reference and short-term memories.
BHMT expression is robustly regulated by taurine.
It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked.
mouse blastocysts are unusual in being able to generate AdoMet not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT
a role for BHMT in energy homeostasis.
BHMT has an important role in Hcy, choline, and one-carbon homeostasis
The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death.
function for Bhmt involving modulation of Shh (显示 SHH 蛋白) signaling to control beta-cell development.
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.
betaine--homocysteine S-methyltransferase 1
, betaine-homocysteine methyltransferase