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Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN562991
Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011
Human Monoclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN520465
Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: Resistance training restores muscle sex steroid hormone steroidogenesis in older men. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Cow (Bovine) Polyclonal SRD5A2 Primary Antibody for WB - ABIN2781789
Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014
Human Polyclonal SRD5A2 Primary Antibody for ELISA - ABIN268809
Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005
Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN451821
Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
A significant positive association of mRNA expression level and a negative association of methylation level of the SRD5A2 gene with the mRNA expression levels of CYP1A1 (显示 CYP1A1 抗体) and CYP1B1 (显示 CYP1B1 抗体) genes in the preputial tissue of patients with hypospadias.
The study described in this article shows that selected SRD5A1 (显示 SRD5A1 抗体) and SRD5A2 polymorphisms can alter the levels of metabolic and hormonal parameters in patients with BPH (显示 GLI3 抗体). Special attention should be paid to the SDR5A2 rs12470143 polymorphism, which is associated with a change in lipid profile, as well as with the inheritance and incidence rate of MetS (显示 ETV3 抗体) among these patients.
mutations of the SRD5A2 gene are the main causes of posterior hypospadias
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC (显示 RPS27A 抗体)) with 5alpha-reductase inhibitors (5-ARI (显示 ARIH1 抗体)).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (显示 ESR1 抗体)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (显示 SHBG 抗体)). No associations between the previously associated SNPs in the genes ESR1 (显示 ESR1 抗体) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (显示 INS 抗体) resistance (IR) rather than obesity.
Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (显示 AR 抗体) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (显示 DPT 抗体) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (显示 SREBF2 抗体) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
3-oxo-5-alpha-steroid 4-dehydrogenase 2
, 5 alpha-SR2
, S5AR 2
, SR type 2
, steroid 5-alpha-reductase 2
, type II 5-alpha reductase
, steroid 5 alpha reductase type2
, prostatic steroid 5-alpha-reductase type II
, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
, steroid-5-alpha-reductase alpha polypeptide 2
, steroid-5-alpha-reductase, alpha polypeptide 2b