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Human POMC Protein expressed in Wheat germ - ABIN1315730
La Rosa, Uccella, Dainese, Marchet, Placidi, Vigetti, Capella: Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas. in Endocrine pathology 2008
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (显示 AGRP 蛋白) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Selenoprotein T (显示 SELT 蛋白) is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ACTH secretion.
Study shows that alpha melanocyte stimulating hormone and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (显示 CEBPB 蛋白) negative transcription in mice adipose tissue.
Our findings demonstrate alphaMSH plays a key role in the prevention of adipose inflammation and inflammatory diseases by down-regulating Akt (显示 AKT1 蛋白)/JNK (显示 MAPK8 蛋白) signal pathway and negatively interacting with FoxOs, which brings up alphaMSH as a novel candidate factor in the adipose anti-inflammation process in obesity.
Data indicate the regulation of energy balance in BMPR1A (显示 BMPR1A 蛋白)-mediated appetite regulation in POMC neurons.
POMC and AgRP (显示 AGRP 蛋白) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (显示 KISS1 蛋白)(ARC (显示 NOL3 蛋白)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC/MC4R (显示 MC4R 蛋白) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (显示 AGRP 蛋白) to POMC neuron GABA connectivity depends on the state of AgRP (显示 AGRP 蛋白) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (显示 LEP 蛋白) sensitivity and glucose sensing of POMC neurons.
Mutation in POMC gene is associated with severe obesity, hypothyroidism, adrenal insufficiency and abnormal reddish hair pigmentation.
In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC (显示 HSPG2 蛋白) pathway, employing PPARgamma (显示 PPARG 蛋白) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
The human beta-endorphin amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM (显示 CYLD 蛋白) analyses.
POMC and MC1R were significantly lower in vitiligo (显示 MITF 蛋白) lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1 (显示 E2F1 蛋白)-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53 (显示 TP53 蛋白)/POMC/Galphas (显示 GNAS 蛋白)/SASH1 (显示 SASH1 蛋白) autoregulatory positive feedback loop is regulated by SASH1 (显示 SASH1 蛋白) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (显示 FN1 蛋白) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (显示 TNF 蛋白), IL-6 (显示 IL6 蛋白) and IL-8 (显示 IL8 蛋白)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (显示 POU1F1 蛋白), SF-1 (显示 NR5A1 蛋白), and ACTH.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (显示 PENK 蛋白)) and prodynorphin (PDYN (显示 PDYN 蛋白)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (显示 CRH 蛋白) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (显示 GJA1 蛋白) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (显示 PHB2 蛋白); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2