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Human POMC Protein expressed in Wheat germ - ABIN1315730
La Rosa, Uccella, Dainese, Marchet, Placidi, Vigetti, Capella: Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas. in Endocrine pathology 2008
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
These findings show that POMC methylation status in the blood of children is associated with metabolic profiles. Therefore, we suggest that the DNA methylation status might serve as a potential epigenetic biomarkers of metabolic syndrome.
Herein, we summarise evidence supporting the potential candidacy in this light of alpha-melanocyte stimulatory hormone, an endogenous peptide hormone and a breakdown product of the neuropeptide pro-opiomelanocortin
Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 and GATA3 appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein; GATA2 = endothelial transcription factor GATA-2; GATA3 = T-cell-specific transcription factor GATA-3)
Mutation in POMC gene is associated with severe obesity, hypothyroidism, adrenal insufficiency and abnormal reddish hair pigmentation.
In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC pathway, employing PPARgamma as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
The human beta-endorphin amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM analyses.
POMC and MC1R were significantly lower in vitiligo lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF, IL-6 and IL-8) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1, SF-1, and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population.
The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
Low circulating plasma alpha-MSH levels are associated with obesity.
hsa-miR-34a can regulate the CRH/CRHR1/POMC axis and may influence body mass index.
these common variants in PCSK1 and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.
ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
the inhibitory effects of alpha-MSH on inflammation are dependent on MC-1 R
Porcine follicular cells (especially granulosa cells) may produce opioid peptides and that gonadotropins may modulate gene expression of their precursors in these cells.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA; P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2