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Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
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Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 16 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
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Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Polyclonal YAP1 Primary Antibody for ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
Overexpression of Yes-associated protein contributes to hepatocellular carcinoma formation, and its overexpression is associated with vascular invasion, low cellular differentiation tumours larger than 5 cm, and TNM (显示 ODZ1 抗体) tumour stage III + IV. [meta-analysis]
we identified YAP-driven AXL (显示 AXL 抗体) overexpression as a mechanism of resistance to EGFR (显示 EGFR 抗体) TKIs in lung cancer cells.
Studies indicate that the transcriptional co-activators YAP and TAZ (显示 TAZ 抗体) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (显示 MMRN1 抗体)) elasticity and cell shape.
Results show that YAP was localized to the nucleus in human cholangiocarcinoma (CCA (显示 FBN2 抗体)) specimens and cell lines and that PDGF (显示 PDGFA 抗体) inhibition decreases YAP nuclear localization and transcriptional activity. Also, tyrosine phosphorylation of YAP by Src (显示 SRC 抗体) family kinases seems to determine subcellular localization in CCA (显示 FBN2 抗体) cells.
These results indicate that Merlin (显示 NF2 抗体)/YAP/cMyc (显示 MYC 抗体)/mTOR (显示 FRAP1 抗体) signaling axis promotes human cholangiocarcinoma (CCA (显示 FBN2 抗体)) cell proliferation by overriding contact inhibition. We propose that overriding cMycmediated contact inhibition is implicated in the development of CCA (显示 FBN2 抗体).
oroxylin A relieved alcoholic liver injury possibly by inhibiting the senescence of hepatocyte, which was dependent on its activation of YAP in hepatocytes.
Knockdown of YAP inhibits the proliferation activity and induces apoptosis of human periodontal ligament stem cells with the involvement of Hippo pathway and has a crosstalk between Erk (显示 EPHB2 抗体) and Bcl-2 (显示 BCL2 抗体) signaling pathways.
we speculate that YAP/TAZ (显示 TAZ 抗体) in dependent of FOS may promote DNMT1 (显示 DNMT1 抗体) and subsequently mediate DNMT1 (显示 DNMT1 抗体)-G9A (显示 EHMT2 抗体) complex involving serine metabolism and the methylation of DNA and histone. We hope that our study will stimulate further studies and a new targeted therapy and early medical intervention for YAP/TAZ (显示 TAZ 抗体) could be a useful option for breast cancer cases complicated with LKB1 (显示 STK11 抗体) deficiency.
Down-regulation of YAP inhibits growth of malignant pleural mesothelioma cells.
YAP1 interacted with TEAD1 (显示 TEAD1 抗体), exerted their transcriptional control of the functional target, glucose transporter 1 (Glut1 (显示 SLC2A1 抗体)).
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
YAP promotes the neurite outgrowth via targeting the promoter of miR (显示 MLXIP 抗体)-29a, and it may be an effective therapeutic medicine for the neural disease.
Plk2 (显示 PLK2 抗体) acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1.
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
MOB1 (显示 HOPX 抗体)-dependent YAP1/TAZ (显示 TAZ 抗体)-TEAD complex functions as a transcriptional repressor of SOX9 (显示 SOX9 抗体) and thereby negatively regulates chondrogenesis.
Hedgehog (显示 SHH 抗体)-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells and their transdifferentiation into myofibroblasts.
The role of Yap and Wwtr1 (显示 WWTR1 抗体) in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
demonstrated the nuclear expression of transcriptional coactivator YAP1 in the limbal and corneal basal epithelial cells and its essential role for maintaining the high proliferative potential of those corneal epithelial progenitor cells in vivo
Taz (显示 TAZ 抗体) and Yap have overlapping functions in promoting myoblast proliferation but Taz (显示 TAZ 抗体) then switches to enhance myogenic differentiation.
identified a pathway involving activation of integrin alpha3 in TA cells that signals through an LATS (显示 LATS1 抗体)-independent FAK (显示 PTK2 抗体)/CDC42 (显示 CDC42 抗体)/PP1A (显示 PPP1CA 抗体) cascade to control YAP-S397 phosphorylation and nuclear localization.
thiazolidinediones (PPARgamma (显示 PPARG 抗体) agonists) promote differentiation of cancer stem cells by restraining YAP transcriptional activity
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (显示 AMOTL2 抗体) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) effector Lef1 (显示 LEF1 抗体).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (显示 TAZ 抗体)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (显示 TAZ 抗体) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa