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抗Human YAP1 抗体:
抗Mouse (Murine) YAP1 抗体:
抗Rat (Rattus) YAP1 抗体:
Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 16 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Polyclonal YAP1 Primary Antibody for ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
Studies indicate that the transcriptional co-activators YAP and TAZ (显示 TAZ 抗体) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (显示 MMRN1 抗体)) elasticity and cell shape.
The authors propose that phosphorylation of Amot (显示 AMOT 抗体)(S176) is a critical post-translational modification that suppresses YAP's ability to promote cell proliferation and tumorigenesis by altering the subcellular localization of an essential YAP co-factor.
YAP maintains human embryonic stem cells pluripotency by preventing WNT3 (显示 WNT3 抗体) expression in response to Activin (显示 Actbeta 抗体), thereby blocking a direct route to embryonic cardiac mesoderm formation.
These results demonstrate a critical role of the activation of YAP/TAZ (显示 TAZ 抗体) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.
the complex structure of YAP WW2 domain with a high-affinity peptide was modeled and examined in detail, which was then used to guide structure-based peptide optimization to obtain several strong domain binders.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (显示 MST1 抗体)/2)/YAP signaling, and that inhibition of miR (显示 MLXIP 抗体)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (显示 SOX2 抗体) and SALL4 (显示 SALL4 抗体).
miR (显示 MLXIP 抗体)-138 may play a suppressive role in the growth and metastasis of non small cell lung cancer cells partly at least by targeting YAP1
our study is the first to indicate the potential role of YAP1 as a common modulator of resistance mechanisms in lung cancer
Our results indicate that YAP promotes erlotinib resistance in the erlotinib-sensitive non-small cell lung cancer cell line HCC827
These findings uncover a suppressive role of SYNPO2 (显示 SYNPO2 抗体) in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ (显示 TAZ 抗体), and suggest that SYNPO2 (显示 SYNPO2 抗体) might provide a potential prognosis marker and novel therapeutic strategy.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Decrease in actin tension and YAP inactivation should be crucially involved in the cytotoxicity of ethanol on HL-1 (显示 ASGR1 抗体) cardiomyocytes.
The results of this study indicated that YAP regulates oligodendrocyte morphology and maturation in response to mechanical factors.
Study found that the extracellular matrix protein laminin-511 (显示 LAMA5 抗体) (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP.
YAP accumulated in nuclei of mammary glands in ErbB2 (显示 ERBB2 抗体)/EGFR (显示 EGFR 抗体)-transgenic mice, suggesting that EGFR (显示 EGFR 抗体) signaling affects YAP in vivo similar to cell culture. ErbB2 (显示 ERBB2 抗体)/EGFR (显示 EGFR 抗体)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Therefore, YAP/TAZ (显示 TAZ 抗体) are crucial for Schwann cells to myelinate developing nerve and to maintain myelinated nerve in adulthood.
Collectively, we have uncovered that AMOT (显示 AMOT 抗体) acts as a YAP stimulator in high glucose level.
YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad (显示 SMAD1 抗体)-dependent BMP and Erk1/2 (显示 MAPK1/3 抗体) signaling pathways.
A crucial role for YAP and TAZ (显示 TAZ 抗体) in the maintenance of the postnatal adrenal cortex.
v-Src (显示 SRC 抗体) prevents nuclear exclusion of YAP through a decrease in the phosphorylation of YAP at Ser127 in multinucleated cells.
Dystrophin-glycoprotein complex component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in mice
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (显示 AMOTL2 抗体) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) effector Lef1 (显示 LEF1 抗体).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (显示 TAZ 抗体)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (显示 TAZ 抗体) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa