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MSK1 抗体

(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
MSK1 抗体  (AA 224-367) MSK1 抗体  (AA 224-367) MSK1 抗体 (AA 224-367) (ABIN7168188)

RPS6KA5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

MSK1 抗体  (AA 271-370) MSK1 抗体  (AA 271-370) MSK1 抗体 (AA 271-370) (ABIN522729)

RPS6KA5 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated

MSK1 抗体  (pSer376) MSK1 抗体  (pSer376) MSK1 抗体 (pSer376) (ABIN7270039)

RPS6KA5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

MSK1 抗体 by 适用

Find MSK1 抗体 for a variety of species such as anti-Mouse MSK1, anti-Human MSK1, anti-Rat MSK1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find MSK1 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find MSK1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MSK1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal MSK1 抗体. Click on a link to go to the corresponding products.

MSK1 抗体 by 克隆

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Find MSK1 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MSK1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7168188
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (4)
Cat. No. ABIN522729
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7270039
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), ICC
Validations
  • (5)
Cat. No. ABIN3043424
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, PLA
Validations
  • (3)
Cat. No. ABIN522728
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN961308
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (4)
Cat. No. ABIN1848238
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, IHC (p), EIA
Validations
  • (4)
Cat. No. ABIN1449449
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN743993
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN743978
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (cc), IHC (p)
Validations
  • (2)
Cat. No. ABIN5557497
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN7180247
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN3185697
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, IHC (p)
Validations
  • (2)
Cat. No. ABIN2879102
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6255276
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our MSK1 抗体

Zhang, Guo, Zhang, Liu, Dong: "Aloe emodin suppresses EGF‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 5215-5220, (2019) (PubMed).

McCoy, Campbell, Deak, Bloomberg, Arthur: "MSK1 activity is controlled by multiple phosphorylation sites." in: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 507-17, (2005) (PubMed).

Roux, Blenis: "ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions." in: Microbiology and molecular biology reviews : MMBR, Vol. 68, Issue 2, pp. 320-44, (2004) (PubMed).

Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).

Abécassis, Rogier, Vazquez, Atfi, Bourgeade: "Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 30474-9, (2004) (PubMed).

Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).

Wiggin, Soloaga, Foster, Murray-Tait, Cohen, Arthur: "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2871-81, (2002) (PubMed).

Jiang, Yu, Tu, Zhao, Zhang, Zhao: "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 87, Issue 3-4, pp. 261-2, (2000) (PubMed).

New, Zhao, Li, Bassett, Feng, Ludwig, Padova, Gram, Han: "Cloning and characterization of RLPK, a novel RSK-related protein kinase." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 1026-32, (1999) (PubMed).

Aliases for MSK1 抗体

ribosomal protein S6 kinase A5 (RPS6KA5) 抗体
ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5) 抗体
ribosomal protein S6 kinase A5 (Rps6ka5) 抗体
3110005L17Rik 抗体
6330404E13Rik 抗体
AI854034 抗体
MSK1 抗体
Msk1 抗体
MSPK1 抗体
RLPK 抗体
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