anti-人 RPS6KA3 抗体 for Immunofluorescence (Paraffin-embedded Sections)

Recommended RPS6KA3 Antibody

抗原
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) 抗体
  • CLS
  • HU-3
  • ISPK-1
  • MAPKAPK1B
  • MRX19
  • RSK
  • RSK2
  • S6K-alpha3
  • p90-RSK2
  • pp90RSK2
  • MPK-9
  • Rsk2
  • RGD1563860
  • zgc:158386
  • ribosomal protein S6 kinase A3
  • ribosomal protein S6 kinase polypeptide 3
  • ribosomal protein S6 kinase, polypeptide 3b
  • RPS6KA3
  • Rps6ka3
  • rps6ka3b
抗原表位
AA 210-260, pSer227
27
26
24
19
16
15
15
15
14
10
8
8
7
6
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
302
205
140
7
6
5
5
3
3
2
2
2
2
1
1
1
1
1
宿主

284
30
克隆类型
多克隆
标记
This RPS6KA3 antibody is un-conjugated
19
15
15
14
14
14
14
9
9
5
5
4
4
4
4
4
4
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
165
76
71
56
32
27
20
14
8
6
3
3
2
1
选项

Available images

产品编号 ABIN745268
$ 339.90
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
7 ABIN745283 FACS IF (p) IHC (p) Rabbit IgG pTyr529 Polyclonal 0
7 ABIN745223 IF (p) IHC (p) WB Rabbit IgG AA 550-600, pThr573 Polyclonal 0
4 ABIN700720 IF (p) IHC (p) WB Rabbit IgG AA 80-130 Polyclonal 0
4 ABIN745193 IF (p) IHC (p) WB Rabbit IgG pSer380 Polyclonal 0
1 ABIN879841 FACS IF (p) Alexa Fluor 488 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN879845 FACS IF (p) Alexa Fluor 350 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN879842 FACS IF (p) Alexa Fluor 555 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN879843 FACS IF (p) Alexa Fluor 647 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN745286 FACS IF (p) Cy3 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN745288 FACS IF (p) Cy5.5 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN745290 FACS IF (p) FITC Rabbit IgG pTyr529 Polyclonal 0
1 ABIN745287 FACS IF (p) Cy5 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN745289 FACS IF (p) Cy7 Rabbit IgG pTyr529 Polyclonal 0
1 ABIN2808934 FACS IF (p) Alexa Fluor 594 Rabbit IgG AA 510-550, pTyr529 Polyclonal 0
1 ABIN878390 IF (p) Alexa Fluor 350 Rabbit IgG AA 550-600, pThr573 Polyclonal 0
1 ABIN878389 IF (p) Alexa Fluor 488 Rabbit IgG AA 550-600, pThr573 Polyclonal 0
1 ABIN878388 IF (p) Alexa Fluor 647 Rabbit IgG AA 550-600, pThr573 Polyclonal 0
1 ABIN878387 IF (p) Alexa Fluor 555 Rabbit IgG AA 550-600, pThr573 Polyclonal 0
1 ABIN745229 IF (p) Cy7 Rabbit IgG AA 550-600, pThr573 Polyclonal 0
1 ABIN745227 IF (p) Cy5 Rabbit IgG AA 550-600, pThr573 Polyclonal 0

General

抗原 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) 抗体
抗原表位 AA 210-260, pSer227
(27), (26), (24), (19), (16), (15), (15), (15), (14), (10), (8), (8), (7), (6), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(302), (205), (140), (7), (6), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
宿主
(284), (30)
克隆类型
多克隆
标记 This RPS6KA3 antibody is un-conjugated
(19), (15), (15), (14), (14), (14), (14), (9), (9), (5), (5), (4), (4), (4), (4), (4), (4)
应用范围 Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(165), (76), (71), (56), (32), (27), (20), (14), (8), (6), (3), (3), (2), (1)
Supplier

RPS6KA3抗体详情

RPS6KA3目标详情 使用细节 贮存及处理 图像
特异性 This antibody will cross react with Ribosomal protein S6 kinase alpha-1 when phosphorylated at Ser221 and Ribosomal protein S6 kinase alpha-6 at Ser232.
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synthetic phosphopeptide derived from human RSK2 around the phosphorylation site of Ser227
亚型 IgG
Plasmids, Primers & others

RPS6KA3目标详情

RPS6KA3抗体详情 使用细节 贮存及处理 图像 回页首
抗原
别名 Rsk2 (RPS6KA3 Antibody 摘要)
背景

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).

Subcellular location: Cytoplasm, Nucleus

Synonyms: Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2, RPS6KA3, ISPK1, MAPKAPK1B, RSK2

基因ID 6197
UniProt P51812
途径 MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades

使用细节

RPS6KA3抗体详情 RPS6KA3目标详情 贮存及处理 图像 回页首
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
限制 仅限研究用

贮存及处理

RPS6KA3抗体详情 RPS6KA3目标详情 使用细节 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months

图像

RPS6KA3抗体详情 RPS6KA3目标详情 使用细节 贮存及处理 回页首
厂商提供的图像
Immunohistochemistry (IHC) image for anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 210-260), (pSer227) antibody (ABIN745268) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-RSK2 (Ser227...
Immunohistochemistry (IHC) image for anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 210-260), (pSer227) antibody (ABIN745268) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Phospho-R...