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Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble (显示 SCRIB 蛋白) PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC (显示 MCC 蛋白) were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2 (显示 RPS6KA3 蛋白); MCC (显示 MCC 蛋白) = mutated in colorectal cancer protein)
RSK1 (显示 RPS6KA1 蛋白) and 3 but not RSK2 (显示 RPS6KA3 蛋白) are down-regulated in breast tumour and are associated with disease progression. RSK (显示 RPS6KA1 蛋白) may be a key component in the progression and metastasis of breast cancer.
Data indicate that S6 kinase 2 (S6K2 (显示 RPS6KB2 蛋白)) can phosphorylate histone H3 (显示 HIST3H3 蛋白) at position Thr45, which may play a role during cell proliferation and/or differentiation.
Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis.
genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (显示 MAP2K1 蛋白) (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder.
Overexpression of RSK3 or RSK4 (显示 RPS6KA6 蛋白) supports tumor cell proliferation upon PI3K (显示 PIK3CA 蛋白) inhibition both in vitro and in vivo therby contributing to drug resistance.
p90RSK2 is dispensable for BCR-ABL (显示 ABL1 蛋白)-induced myeloid leukemia (显示 BCL11A 蛋白), but may be required for pathogenesis and lineage determination in FLT3 (显示 FLT3 蛋白)-internal tandem duplication-induced hematopoietic transformation.
Data show that genetic variation in RPS6KA1 (显示 RPS6KA1 蛋白), RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer.
Characterization of the terminal domain as a protein kinase
chronic activation CREB (显示 CREB1 蛋白) and p90RSK (显示 RPS6KA1 蛋白) in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis
We confirmed that Raf1 (显示 RAF1 蛋白)(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1 (显示 RAF1 蛋白)(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1 (显示 RAF1 蛋白)(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
RSK3 is required for the induction of interstitial cardiac fibrosis in alpha-tropomyosin (显示 TPM1 蛋白) Glu180Gly transgenic mice.
Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy.
p90RSK2 is dispensable for BCR-Abl (显示 ABL1 蛋白)-induced myeloid leukemia (显示 BCL11A 蛋白), but may be required for pathogenesis and lineage determination in Flt3 (显示 FLT3 蛋白)-internal tandem duplication-induced hematopoietic transformation.
activation and translocation of p90 (显示 GPAM 蛋白) ribosomal S6 protein kinase (显示 CDK7 蛋白) requires RANTES (显示 CCL5 蛋白)-mediated chemokine (显示 CCL1 蛋白) transcription in astrocytes
p90Rsk2 and Emi1 functionally interact during oocyte maturation
inhibition of p90RSK (显示 RPS6KA1 蛋白) prevented H2O2-mediated cTnI (显示 TNNC1 蛋白) (Ser (显示 SIGLEC1 蛋白)(23/24)) phosphorylation but not ERK1/2 and PKCalpha (显示 PKCa 蛋白)/betaII activation
p90RSK (显示 RPS6KA1 蛋白) is a novel regulator of cardiac NHE1 (显示 SLC9A1 蛋白) activity by phosphorylating NHE1 (显示 SLC9A1 蛋白) serine 703 and a new pathological mediator of I/R injury in the heart
there is a functional link between S6K1 (显示 RPS6KB1 蛋白) II and CK2 (显示 CSNK2A1 蛋白) signaling, which involves the regulation of S6K1 (显示 RPS6KB1 蛋白) II nuclear export by CK2 (显示 CSNK2A1 蛋白)-mediated phosphorylation of Ser (显示 SIGLEC1 蛋白)-17
RSK2 (显示 RPS6KA3 蛋白) is a key regulator for cell transformation induced by tumor promoters such as EGF (显示 EGF 蛋白) and TPA (显示 PLAT 蛋白).
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ribosomal protein S6 kinase alpha-2
, ribosomal protein S6 kinase, 90kD, polypeptide 2
, 90 kDa ribosomal protein S6 kinase 2
, MAP kinase-activated protein kinase 1c
, MAPK-activated protein kinase 1c
, MAPKAP kinase 1c
, p90-RSK 2
, ribosomal S6 kinase 3
, ribosomal protein S6 kinase alpha 2
, S6K-alpha 2
, protein-tyrosine kinase Mpk-9