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Results showed that RGS1 expression was significantly higher in melanoma than that noted in nevus tissue and correlated with reduced diseasespecific survival. Also, RGS1 expression was also found to be related to the proliferation and migration of melanoma cells through regulation of Galphasmediated inactivation of AKT and ERK.
The rs12022418 in RGS1 showed novel associations in IgA nephropathy.
High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma
RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy.
Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease .
RGS1 as a potential marker of CRC tissue quality
RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts.
Rgs1 has a role in leukocyte trafficking and vascular inflammation
RGS1 and TNFRSF1A polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis.
RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies
Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders.
Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines
RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease.
Overexpression of RGS1 in progenitor pro-B cells (which have little endogenous RGS1) impairs CXCL12-induced focal adhesion kinase activation, chemotaxis, and adhesion to membrane domains.
RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.
RGS1 is (over-) expressed in a broad variety of malignancies
Results validate the role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma.
Undifferentiated spondylarthritis (uSpA) peripheral blood mononuclear cells (PBMCs) carry more expressed genes than PBMCs from ankylosing spondylitis (AS) patients. TNFalpha- and IL-17-inducible RGS1 is a biomarker for uSpA, and to a lesser extent for AS.
Erk1/2 signalling and calcium influx are major effectors of Rgs1-mediated vascular contractile responses.
Rgs1 knockdown increased the size of germinal centers, but decreased the frequency of T follicular helper cells.
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
RGS1 can modulate the expression of costimulatory molecules and cytokine secretion, and interrupt Toll like receptor signal pathways, which suggest that RGS1 may play a role in regulating immune responses.
Rgs1(-/-) mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 and CXCL13. Many of the B-cell follicles in the spleens of Rgs1(-/-) mice have germinal centers even in the absence of immune stimulation.
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
B-cell activation protein BL34
, early response protein 1R20
, immediate-early response 1, B-cell specific
, regulator of G-protein signalling 1
, regulator of G-protein signaling 1
, Regulator of G-protein signaling 1-like protein