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抗Human RAF1 抗体:
抗Rat (Rattus) RAF1 抗体:
抗Mouse (Murine) RAF1 抗体:
Human RAF1 Primary Antibody for IHC - ABIN966940
Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: Vascular access: indications and implications for patient care. in Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2005
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Human Polyclonal RAF1 Primary Antibody for DB, ELISA - ABIN4369727
Gohlke, Kuhn, Case: Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. in Proteins 2004
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Human Monoclonal RAF1 Primary Antibody for FACS, IHC - ABIN969559
Hofmann, Heinrich, Radziwill, Radziwil, Moelling: A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. in Molecular cancer research : MCR 2009
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Human Monoclonal RAF1 Primary Antibody for FACS, IHC - ABIN969560
Takezawa, Okamoto, Yonesaka, Hatashita, Yamada, Fukuoka, Nakagawa: Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. in Cancer research 2009
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Human Monoclonal RAF1 Primary Antibody for WB - ABIN260776
Chiloeches, Mason, Marais: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. in Molecular and cellular biology 2001
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Virus Polyclonal RAF1 Primary Antibody for ICC, IF - ABIN4340713
Retallack, Di Lullo, Arias, Knopp, Laurie, Sandoval-Espinosa, Mancia Leon, Krencik, Ullian, Spatazza, Pollen, Mandel-Brehm, Nowakowski, Kriegstein, DeRisi: Zika virus cell tropism in the developing human brain and inhibition by azithromycin. in Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Polyclonal RAF1 Primary Antibody for IF (p), IHC (p) - ABIN712706
Wu, Dong, Shi, Yu, Fu, Zhang, Cai, Zhao, Peng, Wu, Wu: Regulation of integrin ?V subunit expression by sulfatide in hepatocellular carcinoma cells. in Journal of lipid research 2013
Human Polyclonal RAF1 Primary Antibody for IP, IHC - ABIN222938
Ito, Nagayasu, Okumura-Noji, Lu, Nishida, Miura, Asai, Kheirollah, Nakaya, Yokoyama: Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. in Journal of lipid research 2007
Human Polyclonal RAF1 Primary Antibody for IHC, WB - ABIN361884
Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: Regulation of Raf-1 by direct feedback phosphorylation. in Molecular cell 2005
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Human Polyclonal RAF1 Primary Antibody for IHC, WB - ABIN362494
Fabian, Daar, Morrison: Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. in Molecular and cellular biology 1993
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RAF1 may have a role in survival in hepatocellular carcinoma, and indicate whether sorafenib should be used as a postoperative adjuvant
Mutational activation of Kit-, Ras/Raf/Erk (显示 EPHB2 抗体)- and Akt (显示 AKT1 抗体)- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
Results indicate that des (显示 DES 抗体)-gamma-carboxy prothrombin (显示 F2 抗体) (DCP (显示 ACE 抗体)) antagonizes the inhibitory effects of Sorafenib on hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) through activation of the Raf/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) and PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) signaling pathways.
DiRas3 (显示 DIRAS3 抗体) binds to KSR1 (显示 KSR1 抗体) independently of its interaction with activated Ras and RAF.
RhoA (显示 RHOA 抗体)/ROCK and Raf-1/CK2 (显示 CSNK2A1 抗体) pathway are responsible for TNF-alpha (显示 TNF 抗体)-mediated endothelial cytotoxicity via regulation of the vimentin (显示 VIM 抗体) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
This finding suggests that stringent assemblage of Hsp90 (显示 HSP90 抗体) keeps CRAF kinase equipped for participating in the MAPK (显示 MAPK1 抗体) pathway. Thus, the role of Hsp90 (显示 HSP90 抗体) in CRAF maturation and activation acts as a limiting factor to maintain the function of a strong client like CRAF kinase.
Oncogenic NFIA:RAF1 fusion activation of the MAPK (显示 MAPK1 抗体) pathway is associated with pilocytic astrocytoma.
IGF2BP2 (显示 IGF2BP2 抗体) as a post-transcriptional regulatory mRNA-binding factor, interfering with Raf-1 degradation by miR (显示 MLXIP 抗体)-195, that contributes to Colorectal carcinogenesis.
cdk10 (显示 CDK10 抗体) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (显示 SHC1 抗体), Grb2 (显示 GRB2 抗体), Ras, and Raf-1 link Src (显示 SRC 抗体) to activation of MAPK (显示 MAPK1 抗体) and to the AT(2)-dependent increase in eNOS (显示 NOS3 抗体) expression in PAECs
BRAF (显示 BRAF 抗体) and ROKalpha (显示 ROCK2 抗体) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (显示 EGF 抗体)).
Mechanistically, BRAF (显示 BRAF 抗体) and RAF1 operate independently to balance MAPK (显示 MAPK1 抗体) signaling: BRAF (显示 BRAF 抗体) promotes ERK (显示 EPHB2 抗体) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
A- and B-Raf (显示 SNRPE 抗体) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (显示 VEGFA 抗体) protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (显示 RPS6KA2 抗体) was increased in Raf1(L613V) mice. Constitutive RSK3 (显示 RPS6KA2 抗体) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (显示 EPHX2 抗体) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (显示 EPHX2 抗体) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (显示 PDX1 抗体)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (显示 AKT1 抗体) activity to maintain activation of the RAF1/ERK (显示 EPHB2 抗体) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (显示 SNRPE 抗体) is an important factor in oncogenic C-RAF-mediated tumorigenesis.
Both c-Raf and B-Raf (显示 BRAF 抗体) are required for Ras-induced MEK1 (显示 MAP2K1 抗体) and p42 (显示 EPB42 抗体) MAP kinase (显示 MAPK1 抗体) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF