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FOXF1 (显示 FOXF1 ELISA试剂盒) promotes prostate tumor growth and progression by activating ERK5 signaling
CCh induced TGF-beta1 (显示 TGFB1 ELISA试剂盒) self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity. This autocrine signaling mechanism may be an attractive therapeutic target to block the fibrotic response, which was modulated by the combination of glycopyrronium and indacaterol.
In the current study, five structures of the ERK5 kinase domain co-crystallized with ERK5 inhibitors are reported. Interestingly, three of the compounds bind at a novel allosteric binding site in ERK5, while the other two bind at the typical ATP-binding site.
Our results indicate that overexpression of MAPK7 in human OS cells could promote cell proliferation, migration and invasion, whereas knockdown of MAPK7 expression had the opposite effect. All the results suggest that MAPK7 may serve as a potent target for drug development.
Statin mediated ERK5 activation and the resulting decrease in cardiac endothelial cell permeability may contribute to the cardioprotective effects of statins in reducing doxorubicin-induced cardiotoxicity.
These findings suggest that atherogenic conditions critically regulate platelet CD36 (显示 CD36 ELISA试剂盒) signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK (显示 MAPK1 ELISA试剂盒) ERK5.
expression of miR (显示 MLXIP ELISA试剂盒)-143 in osteosarcoma cells inhibited cell proliferation and migration/invasion. Bioinformatics and luciferase reporter assays confirmed that MAPK7 was targets gene of miR (显示 MLXIP ELISA试剂盒)-143.
miR (显示 MLXIP ELISA试剂盒)-143 down-regulated its target ERK5, leading to the suppression of epithelial-mesenchymal transition induced by GSK-3beta (显示 GSK3b ELISA试剂盒)/Snail (显示 SNAI1 ELISA试剂盒) signaling of breast cancer.
this study revealed the functional and mechanistic links between CDK5 (显示 CDK5 ELISA试剂盒) and the oncogenic ERK5-AP-1 (显示 FOSB ELISA试剂盒) signaling pathway in the pathogenesis of colorectal cancer.
Present study revealed the positive role of ERK5/AP-1 (显示 FOSB ELISA试剂盒) in benzidine-provoked urocystic epithelial-mesenchymal transition and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 (显示 FOSB ELISA试剂盒) pathway.
These findings define an antagonistic function of ATM (显示 ATM ELISA试剂盒) and MAPK7 in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 inhibits thymic lymphoma growth in Atm (显示 ATM ELISA试剂盒)-/- mice by partially restoring the DNA damage response in thymocytes.
Erk5 role in the cardiac mitochondria and the Pgc-1alpha (显示 PPARGC1A ELISA试剂盒) regulation
Erk5 MAP kinase (显示 MAPK1 ELISA试剂盒) is activated in response to PDGF (显示 PDGFA ELISA试剂盒)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (显示 MAP3K2 ELISA试剂盒), Mek1 (显示 MAP2K1 ELISA试剂盒)/2, Mek5 (显示 MAP2K5 ELISA试剂盒), PI3-kinase (显示 PIK3CA ELISA试剂盒) and protein kinase C (PKC (显示 PKC ELISA试剂盒)).
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 and Brd4 (显示 BRD4 ELISA试剂盒) in pluripotency regulation of mouse embryonic stem cells have been revealed.
These results suggest that YAP (显示 YAP1 ELISA试剂盒) promotes muscle differentiation by activating the Abl (显示 ABL1 ELISA试剂盒)/Src (显示 SRC ELISA试剂盒)/MEKK3 (显示 MAP3K3 ELISA试剂盒)/MEK5 (显示 MAP2K5 ELISA试剂盒)/ERK5 kinase cascade.
our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell infiltrates in prostate cancer
This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5/Nrf2 (显示 NFE2L2 ELISA试剂盒) signaling, which can be new agent for osteoporosis.
Fluid shear stress acts on the Galphaq (显示 GNAQ ELISA试剂盒)-ERK5 signaling pathway to upregulate Cyclin B1 (显示 CCNB1 ELISA试剂盒) and CDK1 (显示 CDK1 ELISA试剂盒) expression, thereby resulting in MC3T3-E1 cell proliferation.
Data showed that expression of the MKK7 (显示 MAP2K7 ELISA试剂盒) gene in wild-type plants is induced by pathogen infection. Reducing mRNA levels of MKK7 (显示 MAP2K7 ELISA试剂盒) by antisense RNA expression not only compromises basal resistance, but also blocks the induction of SAR (显示 SRL ELISA试剂盒).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
, BMK1 kinase
, MAP kinase 7
, MAPK 7
, big MAP kinase 1
, extracellular signal-regulated kinase 5
, extracellular-signal-regulated kinase 5
, extracellular signal regulated kinase 5
, mitogen activated protein kinase 7
, mitogen-activated kinase 7
, Big MAP kinase 1
, Extracellular signal-regulated kinase 5
, LOW QUALITY PROTEIN: mitogen-activated protein kinase 7
, bmk I
, mitogen-activated protein kinase 7 L homeolog