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抗Human MAPK6 抗体:
抗Rat (Rattus) MAPK6 抗体:
抗Mouse (Murine) MAPK6 抗体:
Rat (Rattus) Monoclonal MAPK6 Primary Antibody for BI, IF - ABIN967749
Clark, Hynes: Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. in The Journal of biological chemistry 1996
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Human Monoclonal MAPK6 Primary Antibody for FACS, ELISA - ABIN966092
Déléris, Rousseau, Coulombe, Rodier, Tanguay, Meloche: Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. in Journal of cellular physiology 2008
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Human Monoclonal MAPK6 Primary Antibody for FACS, ELISA - ABIN969115
Klinger, Turgeon, Lévesque, Wood, Aagaard-Tillery, Meloche: Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (显示 PRKAA1 抗体)/p38 MAPK (显示 MAPK14 抗体)-ERK3 (显示 MAPK4 抗体)/mTORC1 pathways. ERK3 (显示 MAPK4 抗体) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (显示 TDP2 抗体) activity and discovered a new role of ERK3 (显示 MAPK4 抗体) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (显示 TOP2A 抗体) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (显示 MAPK4 抗体) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (显示 NCOA3 抗体)/SP-1 (显示 PSG1 抗体)-mediated VEGFR2 (显示 KDR 抗体) expression.
These findings further expand distinct roles of cyclin D3 (显示 CCND3 抗体) and suggest the potential activity of ERK3 (显示 MAPK4 抗体) in cell proliferation.
Cdc14A (显示 CDC14A 抗体) forms a stable complex with atypical mitogen-activated protein kinase (显示 MAPK1 抗体) Erk3 (显示 MAPK4 抗体) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (显示 MAPK4 抗体) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (显示 MAPK1 抗体) signaling.
A previously unknown role for ERK3 (显示 MAPK4 抗体) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (显示 NCOA3 抗体) and regulating SRC-3 (显示 NCOA3 抗体) proinvasive activity by site-specific phosphorylation.
ERK3 (显示 MAPK4 抗体) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (显示 CDKN1A 抗体) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (显示 RYK 抗体) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (显示 RYK 抗体)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (显示 MAPKAPK5 抗体) or PRAK (显示 MAPKAPK5 抗体)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (显示 MAPKAPK5 抗体)).
p38gamma (显示 MAPK12 抗体) MAP kinase (显示 MAPK1 抗体) (SAPK3/p38gamma (显示 MAPK12 抗体)) was shown to catalyse phosphorylation of SAP97 (显示 DLG1 抗体).
Results show that Cdo (显示 CDO1 抗体) is important for full Abl kinase activity, and Abl (显示 ABL1 抗体) is necessary for full activation of p38 MAPK (显示 MAPK14 抗体), during myogenic differentiation.
Genetic and biochemical evidences not only show that MEK1 (显示 MAP2K1 抗体)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (显示 MAP2K1 抗体)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3 (显示 MAPK3 抗体)/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF (显示 CEBPZ 抗体) expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (显示 MAP2K5 抗体)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (显示 MAPK1 抗体) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (显示 MAPK3 抗体)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 (显示 MAPK3 抗体) and MPK6 can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 抗体)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 抗体) protein in vitro.
AIK1-MKK5 (显示 MAP2K5 抗体)-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6