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MAP3K4 蛋白

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
MAP3K4 Protein (AA 1312-1608) (GST tag) MAP3K4 Protein (AA 1312-1608) (GST tag) MAP3K4 Protein (AA 1312-1608) (GST tag) (ABIN5569793)

MAP3K4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active

MAP3K4 Protein (AA 1201-1300) (GST tag) MAP3K4 Protein (AA 1201-1300) (GST tag) MAP3K4 Protein (AA 1201-1300) (GST tag) (ABIN1310218)

MAP3K4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

MAP3K4 Protein (AA 1-1608) (Strep Tag) MAP3K4 Protein (AA 1-1608) (Strep Tag) MAP3K4 Protein (AA 1-1608) (Strep Tag) (ABIN3093617)

Crystallography grade MAP3K4 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

MAP3K4 蛋白 by Grade

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MAP3K4 蛋白 by Origin

Find MAP3K4 蛋白 for a variety of species such as anti-Human MAP3K4, anti-Mouse MAP3K4, anti-Rat MAP3K4. The species listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 蛋白 by Source

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MAP3K4 蛋白 by 蛋白类型

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MAP3K4 蛋白 by 应用范围

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MAP3K4 蛋白 by 生物活性

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Popular MAP3K4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect cells (Sf21)
Validations
  • (2)
Cat. No. ABIN5569793
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310218
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3093617
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3131271
Quantity 1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2750508
Quantity 5 applications
Datasheet Datasheet

Aliases for MAP3K4 蛋白

mitogen activated protein kinase kinase kinase 4 (Map3k4) 蛋白
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) 蛋白
mitogen-activated protein kinase kinase kinase 4 (Map3k4) 蛋白
D17Rp17 蛋白
D17Rp17e 蛋白
MAPKKK4 蛋白
Mek4b 蛋白
MEKK4 蛋白
MEKK 4 蛋白
Mekk4 蛋白
mKIAA0213 蛋白
MTK1 蛋白
PRO0412 蛋白
RP17 蛋白
Rp17a 蛋白
Tas 蛋白
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