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|抗原||Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) 抗体|
|抗原表位||AA 27-135 其他选择|
|适用||犬, 人, 小鼠, 大鼠 其他选择|
|标记||This MAP3K3 antibody is un-conjugated 其他选择|
Immunofluorescence (IF), Western Blotting (WB)
|Supplier||Log in to see|
MAP3K3抗体详情MAP3K3目标详情 使用细节 贮存及处理 References for anti-MAP3K3 antibody (ABIN968365) 图像
|交叉反应||小鼠, 大鼠, 犬|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
|纯化方法||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|免疫原||Human MEKK3 aa. 27-135|
MAP3K3目标详情MAP3K3抗体详情 使用细节 贮存及处理 References for anti-MAP3K3 antibody (ABIN968365) 图像 回页首
|别名||MEKK3 (MAP3K3 Antibody 摘要)|
|背景||The Ras signaling pathway links signals from growth factor receptors to activation of the MEK/ERK kinases. This cascade of phosphorylation leads to cell growth and differentiation. External stimuli such as endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression. These processes are controlled by the MKK3/p38MAP kinase cascade. A third pathway responsive to environmental stress, cell death, or apoptosis is regulated by SEK/SAPKs. When overexpresssed, MEKK3 is a kinase that is capable of activating both the ERK and SAPK cascades. MEKK3 is 626 amino acids long and is ubiquitously expressed. It is positioned upstream of SEK and MEK in the signaling pathways and directly phosphorylates these enzymes. Overexpression of MEKK3 results in the activation of NFkappaB. Thus, MEKK3 represents an emerging family of kinases that is capable of inducing more than one signaling pathway. This indicates that specificity in the signaling cascades is probably achieved by effector kinases such as the ERKs and SAPKs.|
使用细节MAP3K3抗体详情 MAP3K3目标详情 贮存及处理 References for anti-MAP3K3 antibody (ABIN968365) 图像 回页首
Related Products: ABIN967389, ABIN968535
贮存及处理MAP3K3抗体详情 MAP3K3目标详情 使用细节 References for anti-MAP3K3 antibody (ABIN968365) 图像 回页首
|缓冲液||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store undiluted at -20°C.|
References for anti-MAP3K3 antibody (ABIN968365)MAP3K3抗体详情 MAP3K3目标详情 使用细节 贮存及处理 图像 回页首
Yang, Lai, Lai, Hsu, Kuo, Yu, Lin, Yang, Kuo, Wu, Chung: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, 2010
Ellinger-Ziegelbauer, Brown, Kelly, Siebenlist et al.: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, 1997
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