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抗Rat (Rattus) MAP3K2 抗体:
抗Human MAP3K2 抗体:
抗Mouse (Murine) MAP3K2 抗体:
Human Monoclonal MAP3K2 Primary Antibody for ICC, ELISA - ABIN969272
Kurada, Li, Mulherkar, Subramanian, Prasad, Prabhakar: MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment. in The Journal of biological chemistry 2009
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Compound 1s displayed activity in cell-based assays in which it inhibited ERK5 (显示 MAPK7 抗体) pathway activation in cells and inhibited cell migration in a scratch assay. Thus, we have identified a scaffold that has promising potential to be developed into a highly selective and potent inhibitor of MEKK2. Information from these SAR (显示 SARDH 抗体) studies provides specific guidance for the future design of MEKK2 inhibitor probes.
miR (显示 MLXIP 抗体)-34c-3p may regulate triple-negative breast cancer progression by directly targeting the 3'-untranslated region of mitogen-activated protein kinase kinase kinase 2 (MAP3K2).
Study found miR (显示 MLXIP 抗体)-186 expression significantly decreased in lung cancer tissues and cells and MAP3K2 expression increased in the same cancer tissues. Also, results confirmed that MAP3K2 is a target gene of miR (显示 MLXIP 抗体)-186 and both expression correlated with prognosis.
SMYD3 (显示 SMYD3 抗体)-mediated methylation of MAP3K2 increases mutant K-Ras (显示 HRAS 抗体)-induced activation of ERK1/2 (显示 MAPK1/3 抗体). (Review)
Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2
HBXIP (显示 HBXIP 抗体) activated ERK1/2 (显示 MAPK1/3 抗体) through up-regulating MEKK2.
MEKK2 has a novel function as a regulator of ubiquitylation-dependent paxillin (显示 PXN 抗体) redistribution in breast tumour cells.
EBV microRNA BART (显示 BSND 抗体) 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells.
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5 (显示 MAP2K5 抗体)-ERK5 (显示 MAPK7 抗体) signaling.
methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
Erk5 (显示 MAPK7 抗体) MAP kinase (显示 MAPK1 抗体) is activated in response to PDGF (显示 PDGFA 抗体)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1 (显示 MAP2K1 抗体)/2, Mek5 (显示 MAP2K5 抗体), PI3-kinase (显示 PIK3CA 抗体) and protein kinase C (PKC (显示 PKC 抗体)).
FGF2 (显示 FGF2 抗体)/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin (显示 CTNNB1 抗体) activation, and this pathway is a key regulator of bone formation by osteoblasts
Stk38 (显示 STK38 抗体) protein kinase (显示 CDK7 抗体) has a role in inhibiting TLR9 (显示 TLR9 抗体)-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
MEKK2 is regulated through a phosphorylation-dependent association with 14-3-3 (显示 YWHAQ 抗体), a group of adapters that modulate dimerization and association between proteins
MEKK2 signaling contributes to right ventricular hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced pulmonary hypertension.
MEKK2 alone can suppress T-cell TGF-beta (显示 TGFB1 抗体) responses. MEKK2 or MEKK3 (显示 MAP3K3 抗体) can cause ERK1/2 (显示 MAPK1/3 抗体) to phosphorylate SMAD2 (显示 SMAD2 抗体)/3 and suppress R-SMAD (显示 SMAD1 抗体)-dependent transcription. MEKK2 and MEKK3 (显示 MAP3K3 抗体) play overlapping roles in regulating Th-cell differentiation via TGF-beta (显示 TGFB1 抗体)
Data show that HDAC4 (显示 HDAC5 抗体) binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2.
Data from experiments with Mekk2(-/-) mice show that MEKK2 may be required for controlling the strength of T cell receptor/CD3 (显示 CD3E 抗体) signaling.
PB1 (显示 GPR97 抗体) domain mediates the association of MEKK2 and MEKK3 (显示 MAP3K3 抗体) with MEK5 (显示 MAP2K5 抗体) and that the respective PB1 (显示 GPR97 抗体) domains of these kinases are critical for regulation of the ERK5 (显示 MAPK7 抗体) pathway.
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
mitogen-activated protein kinase kinase kinase 2
, MAP/ERK kinase kinase 2
, MAPK/ERK kinase kinase 2
, MEK kinase 2
, MEKK 2
, mitogen activated protein kinase kinase kinase 2
, protein kinase MEKK2b