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The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke and suggests that MKK3 could be a therapeutic target.
MEK2 (显示 MAP2K2 蛋白) was essential for the phosphorylation of MKK3/MKK6 (显示 MAP2K6 蛋白) and p38 MAPK (显示 MAPK14 蛋白) that directly impacted on cyclin D1 (显示 CCND1 蛋白) expression.
High MKK3 expression is associated with lung cancer.
The results revealed upregulation of MEK3, as well as phosphorylated MEK3 and phosphorylated p38 MAPK (显示 MAPK14 蛋白), in CMM patients. These results provide a "fingerprint" for mechanistic studies of CMM in the future and highlight the importance of MEK3-p38 MAPK (显示 MAPK14 蛋白) activation in CMM.
miR (显示 MLXIP 蛋白)-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 (显示 IL6 蛋白) and TNF-alpha (显示 TNF 蛋白), in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
MKK3 overexpression upregulated the cyclin-dependent kinase (显示 CDK1 蛋白) inhibitors, p16 INK4A and p15 INK4B (显示 CDKN2B 蛋白) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression.
Our results suggest that asthma is associated with MKK3 over-expression in CD8 (显示 CD8A 蛋白)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia
MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3.
study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls
study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation
The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke.
MAP2K6 (显示 MAP2K6 蛋白) functions in mouse testis determination, via positive effects on Sry (显示 SRY 蛋白), and a minor role for MAP2K3.
ATF3 (显示 ATF3 蛋白) upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38 (显示 CRK 蛋白)-transforming growth factor-beta signaling.
miR (显示 MLXIP 蛋白)-21a-5p inhibited BPA (显示 DST 蛋白) induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK (显示 MAPK14 蛋白) in 3T3-L1 cells
this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.
Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 (显示 AKT1 蛋白) pathway.
MKK3 and MKK6 (显示 MAP2K6 蛋白) differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 (显示 MAP2K6 蛋白) likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
results designate MKK3 as a novel, positive regulator of SCF (显示 KITLG 蛋白)-induced mast cell proliferation and a critical signaling protein for AP-1 (显示 JUN 蛋白)-dependent IL-6 (显示 IL6 蛋白) production
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
MAP kinase kinase 3
, MAPK/ERK kinase 3
, MAPKK 3
, MEK 3
, SAPK kinase 2
, dual specificity mitogen-activated protein kinase kinase 3
, stress-activated protein kinase kinase 2
, mitogen activated protein kinase kinase 3
, protein kinase, mitogen-activated, kinase 3
, MAP kinase kinase 6
, MAPKK 6
, dual specificity mitogen-activated protein kinase kinase 6
, mitogen-activated protein kinase kinase 3