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Human JNK Protein expressed in Wheat germ - ABIN1310303
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493
Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015
aken together, these results reveal that inactivation of Rpd3 (显示 HDAC1 蛋白) independently regulates JNK and Yki (显示 YAP1 蛋白) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (显示 HDAC1 蛋白) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (显示 EGFR 蛋白)) pathway in the lateral epidermis for sustained dpp (显示 TGFb 蛋白) expression in the LE. Specifically, we demonstrate that Egfr (显示 EGFR 蛋白) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (显示 ETS1 蛋白)-domain factor Ets21c and the nuclear receptor Ftz-F1 (显示 NR5A2 蛋白), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (显示 ROS1 蛋白)/JNK/p38 (显示 MAPK14 蛋白)/Upd (显示 UROD 蛋白) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (显示 NOTCH1 蛋白)-Src (显示 SRC 蛋白) synergy.
This study demonstrated that the mechanism by which Bsk (显示 FRK 蛋白) is required for pruning is through reducing the membrane levels of the adhesion molecule (显示 NCAM1 蛋白) Fasciclin II (显示 NCAM2 蛋白) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (显示 AMPH 蛋白)-PNP (显示 NP 蛋白)) and magnesium.
Thus, the present study indicated that parkin (显示 PARK2 蛋白) knockout inhibits neural stem cell differentiation by JNK-dependent proteasomal degradation of p21 (显示 CDKN1A 蛋白).
JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular reactive oxygen species generation.
ERK1 (显示 MAPK3 蛋白) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (显示 JUN 蛋白) Activity and Cell Transformation.
TGM2 (显示 TGM2 蛋白) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (显示 FOSB 蛋白)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (显示 LYZ 蛋白) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (显示 MAP2K7 蛋白), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (显示 CD274 蛋白) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (显示 CD274 蛋白)/JNK/Cyclin D2 (显示 CCND2 蛋白) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (显示 HTRA1 蛋白) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (显示 GADD45A 蛋白) essentially suppresses the MKK7 (显示 MAP2K7 蛋白)-JNK pathway and suggest that differentially expressed GADD45 (显示 GADD45A 蛋白) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (显示 SIRT6 蛋白) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 蛋白)) to DNA break sites and for efficient repair of double-strand break.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (显示 PLA2G2A 蛋白) keratinocytes showed enhanced activation of EGFR (显示 EGFR 蛋白) and JNK1/2 that led to c-Jun (显示 JUN 蛋白) activation.
p53 (显示 TP53 蛋白) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (显示 PTF1A 蛋白)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (显示 PTF1A 蛋白)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (显示 CCL20 蛋白) secretion
BOC (显示 BOC 蛋白) interacts with ABL (显示 ABL1 蛋白) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (显示 NLRP3 蛋白) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (显示 NLRP3 蛋白) inflammasome activation.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (显示 CASP3 蛋白)-dependent Proteolysis of JNK1-2 and Bid (显示 BID 蛋白).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (显示 GUSB 蛋白).
Data show that the death pathway is independent of ERK (显示 MAPK1 蛋白) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 蛋白) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (显示 CA2 蛋白))+ and ROS (显示 ROS1 蛋白) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (显示 CA2 蛋白))+/CaMs and MAP kinase (显示 MAPK1 蛋白) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (显示 ROS1 蛋白) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (显示 MAPK14 蛋白) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (显示 AXIN1 蛋白)/JNK signaling and its inhibitor Aida (显示 AIDA 蛋白) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (显示 MMP13 蛋白) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (显示 INS 蛋白)-IGF-1 (显示 IGF1 蛋白) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (显示 MAPK1 蛋白) (MAPK (显示 MAPK1 蛋白)) signaling pathway, which is regulated by MLK-1 (显示 MAP3K9 蛋白) MAPK (显示 MAPK1 蛋白) kinase kinase (MAPKKK), MEK-1 (显示 MAP2K1 蛋白) MAPK (显示 MAPK1 蛋白) kinase (MAPKK), and KGB-1 (显示 KCNJ3 蛋白) JNK-like MAPK (显示 MAPK1 蛋白).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8