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Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN388369
Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009
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Human Polyclonal GJA1 Primary Antibody for IHC - ABIN965918
Solan, Fry, TenBroek, Lampe: Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. in Journal of cell science 2003
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Human Polyclonal GJA1 Primary Antibody for ICC, IHC (fro) - ABIN5518645
Peng, Dai, Ji, Dai: The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. in European journal of pharmacology 2010
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Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN3043758
Li, Tang, Liang, Li, Wang, Song, Zheng, Xi, Zhang, Hescheler, Zhu: Coculture of embryonic ventricular myocytes and mouse embryonic stem cell enhance intercellular signaling by upregulation of connexin43. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013
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Chicken Polyclonal GJA1 Primary Antibody for WB - ABIN2473077
Donovan: Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig. in British journal of pharmacology 1975
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Dog (Canine) Polyclonal GJA1 Primary Antibody for IF (p), IHC (p) - ABIN671451
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
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Human GJA1 Primary Antibody for IHC - ABIN965917
Matsushita, Kurihara, Watanabe, Okada, Sakai, Amano: Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006
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Human Monoclonal GJA1 Primary Antibody for FACS - ABIN4898466
Szaraz, Librach, Maghen, Iqbal, Barretto, Kenigsberg, Gauthier-Fisher, Librach: In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells. in Stem cells international 2016
Bird (Avian) Polyclonal GJA1 Primary Antibody for WB - ABIN2473076
Bao, Reuss, Altenberg: Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. in The Journal of biological chemistry 2004
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Bird (Avian) Polyclonal GJA1 Primary Antibody for WB - ABIN152643
Sahin, Akdemir, Tuzcu, Sahin, Onderci, Ozercan, Ilhan, Kilic, Seren, Kucuk: Genistein suppresses spontaneous oviduct tumorigenesis in quail. in Nutrition and cancer 2010
These data suggest that chronic exposure to glucose-evoked TGFbeta1 (显示 TGFB1 抗体) induce an increase in CX26 (显示 GJB2 抗体) and CX43 expression, consistent with changes observed in tubular epithelia from patients with diabetic nephropathy.
Cx43, a transmembrane protein initially described as a gap junction protein, participates in all forms of communication including extracellular vesicles, tunnelling nanotubes or gap junctions. (Review)
One novel homozygous variant c.169C>T and one heterozygous SNP c.624C>T (rs530633057) were determined in 124 SUNDS cases (one case for each detected variant) and none of the 125 healthy controls. This is the first report of GJA1 gene variations in SUNDS in the Chinese Han population, which suggests a novel susceptibility gene for Chinese sudden unexplained nocturnal death syndrome.
The functional modulation of connexin 43 (Cx43) indicate its involvement in olfactory ensheathing cells-conditioned medium (OEC-CM) mediated neuroprotection.
To determine the role of connexin43 hemichannels in diabetic retinopathy, changes in cytokine and ATP release were evaluated after treatment with Peptide5, a connexin43 hemichannel blocker. Co-application of glucose and cytokines increased the secretion of IL-6 (显示 IL6 抗体), IL-8 (显示 IL8 抗体), MCP-1 (显示 CCL2 抗体), sICAM-1, VEGF (显示 VEGFA 抗体) and ATP. Peptide 5 blocked this and prevented ATP release, indicating a role for connexin-43 hemichannels.
human Cx40 (显示 GJA5 抗体)/Cx45 (显示 GJC1 抗体) and Cx43/Cx45 (显示 GJC1 抗体) heterotypic gap junctions were investigated by recombinant expression in GJ deficient cells.
The results of this study show that total (whole-cell) Cx43, but not Cx30 (显示 GJB6 抗体), protein levels are upregulated in the sclerotic hippocampus, both in human and experimental experimental temporal lobe epilepsy.
Data suggest that the level of CX43 expression in breast tumors is altered when compared to the normal tissue. While some reports show that its levels decrease, other evidence suggests that its levels are increased and protein localization shifts from the plasma membrane to cytoplasm. In either case, the prevailing theory is that breast tumor cells have reduced gap junction communication within primary tumors. [review]
an oncogenic E3 ubiquitin ligase (显示 MUL1 抗体) promotes loss of gap junctions and Cx43 degradation in human carcinoma cells.
Administration metformin can protect the H9c2 cells against hyperglycemia-induced apoptosis and Cx43 down-regulation, in part, mediated through the induction of autophagy pathway
The tenotomy mice treated with Cx43 shRNA injection indicated a reduction in total heterotopic ossification (HO) volume at 4 and 8 weeks after injury.
The treatment of Salmonella enterica serovar choleraesuis or resveratrol in murine melanoma cells demonstrated the ability of reducing IDO1 (显示 IDO1 抗体) production through upregulating Cx43.
At 3days after the first tamoxifen injection, Akt1 (显示 AKT1 抗体)(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43) and connexin-interacting protein zonula occludens-1 (ZO-1 (显示 TJP1 抗体)). Furthermore, Akt1 (显示 AKT1 抗体)/2 silencing significantly decreased both Cx43 and ZO-1 (显示 TJP1 抗体) expression
we confirmed that Th1 (显示 HAND1 抗体) cell-conditioned medium decreased Cx43 protein levels in mixed glial cell cultures. These findings suggest that Th1 (显示 HAND1 抗体) cell-derived IFNg (显示 IFNG 抗体) activates microglia to release IL-1b (显示 IL1B 抗体) that reduces Cx43 gap junctions in astrocytes. Thus, Th1 (显示 HAND1 抗体)-dominant inflammatory states disrupt astrocytic intercellular communication and may exacerbate multiple sclerosis.
Results suggest that gap junctions are present not only among tanycytes, but also between tanycytes and the axons of hypophysiotropic neurons. Cx43 hemichannels may also facilitate the transport between tanycytes and extracellular fluids, including the cerebrospinal fluid, extracellular space of the median eminence and bloodstream.
The most aggressive trans-differentiated (phenotypically epithelial) cell strain, NIH3T3x8x3 acquired metastatic phenotypic changes accompanied ~40% reduction in endogenous or radiation-induced connexin-43 expression/mitochondrial translocation. Parental (NIH3T3) and reverting (NIH3T3x12) strains lacked hyperradiosensitivity and had distinct radiation-induced Cx43 translocation into mitochondria.
Cx43 is up-regulated in the dentate gyrus following traumatic brain injury and is expressed on vimentin (显示 VIM 抗体)-positive cells in the subgranular zone. Treatment of cultured cells with alpha-connexin Carboxyl Terminal (alphaCT1) peptide substantially reduced proliferation and increased caspase 3 (显示 CASP3 抗体)/7 expression on NSPCs in a dose-dependent manner. alphaCT1 exposure also reduced overall expression of Cx43 and phospho (p)-Serine368.
the Gja1 gene showed an upregulated profile in the Light and Inflexible ethanol drinkers when compared to the Control group.
these findings provide evidence that Cx43 and Runx2 (显示 RUNX2 抗体) functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation
The mosaic of Cx43/Cx45 (显示 GJC1 抗体)-puncta along cerebral cortex Bergmann glial processes raises the possibility of differential regulation of coupling between these processes via separate but adjacent Cx43-containing and Cx45 (显示 GJC1 抗体)-containing gap junctions channels having different permeability and other biophysical properties or may contribute to coupling between Bergmann glia and Purkinje cells.
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (显示 HSP90AA1 抗体) responsible for proper folding of procollagen molecules.
Hapln1a (显示 HAPLN1 抗体)-ECM (显示 MMRN1 抗体) stabilizes the secreted growth factor (显示 WNT2 抗体) Semaphorin3d (Sema3d (显示 SEMA3D 抗体)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a (显示 HAPLN1 抗体) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
Sema3d (显示 SEMA3D 抗体) functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (显示 COL6A1 抗体)) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R (显示 IGF1R 抗体) and AT-1R in AT-II and IGF-1 (显示 IGF1 抗体)-induced Cx43 expression in SV SMCs involving Erk 1 (显示 MAPK3 抗体)/2 and downstream activation of the AP-1 (显示 JUN 抗体) transcription factor.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (显示 GJC1 抗体).
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA (显示 RHOA 抗体) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 (显示 TGFB1 抗体) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (显示 GJB2 抗体), Cx32 (显示 GJB1 抗体), and Cx43
CBN (显示 CALB1 抗体) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin (显示 CDH1 抗体) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
These findings indicated that Cx43/miR (显示 MYLIP 抗体)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (显示 CDK4 抗体) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
, gap junction 43 kDa heart protein
, gap junction alpha-1 protein
, gap junction membrane channel protein alpha 1
, alpha 1 connexin
, gap junction protein, alpha 1
, short fin protein
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, alpha 1 gap junction protein
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1