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Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016
Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001
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The present study demonstrated that the downregulation of filaggrin (显示 FLG 蛋白) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (显示 STAT3 蛋白)-dependent pathways.
The results of the present study suggested that the therapeutic effect of TGP (显示 TGM4 蛋白) on psoriasis may be mediated by modulation of the p38 MAPK (显示 MAPK14 蛋白)/NFkappaB (显示 NFKB1 蛋白) p65 (显示 GORASP1 蛋白) signaling pathway. The results of the present study contribute to the understanding of the role of TGP (显示 TGM4 蛋白) in the treatment of psoriasis. The present study provides insights suggesting that p38 MAPK (显示 MAPK14 蛋白) may be a novel regulatory signaling pathway for the treatment of psoriasis.
L5-LDL, a naturally occurring mild oxidized LDL, induced G-CSF (显示 CSF3 蛋白) and GM-CSF (显示 CSF2 蛋白) production in human macrophages through LOX-1 (显示 OLR1 蛋白), ERK2, and NF-kappaB (显示 NFKB1 蛋白) dependent pathways
the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK (显示 MYLK 蛋白)) in HepG2 cells.
Summarizing the obtained results we can postulate p38 (显示 CRK 蛋白) implication in H2O2-induced senescence of hMESCs, and suggest p38 (显示 CRK 蛋白) inhibition as a promising approach in prevention of premature senescence.
TGFB1 (显示 TGFB1 蛋白)-mediated PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) and p38 MAP kinase (显示 MAPK14 蛋白) dependent alternative splicing of fibronectin (显示 FN1 蛋白) extra domain A in human podocyte culture has been reported.
These data suggest ebselen may inhibit ROS (显示 ROS1 蛋白) production triggered by H. pylori LPS (显示 IRF6 蛋白) treatment via GPX2 (显示 GPX2 蛋白)/4 instead of TLR4 (显示 TLR4 蛋白) signaling and reduce phosphorylation of p38 MAPK (显示 MAPK14 蛋白), resulting in altered production of IL8 (显示 IL8 蛋白). Ebselen may, therefore, be a potential therapeutic agent to mediate H. pylori LPS (显示 IRF6 蛋白)-induced cell damage.
SHP-2 (显示 PTPN11 蛋白) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (显示 IL17C 蛋白) signaling.
intact keratin filaments are regulators for PKB/Akt (显示 AKT1 蛋白) and p44 (显示 GTF2H2 蛋白)/42 activity, basal and in response to stretch.
High MAPK1 (显示 MAPK3 蛋白) expression is associated with gastric cancer.
M-CSF (显示 CSF1R 蛋白)-evoked ERK1/2 activation was decreased, whereas AKT (显示 AKT1 蛋白) activation was enhanced in SHP2 (显示 PTPN11 蛋白)-deficient BMMs. ERK1/2, via its downstream target RSK2 (显示 RPS6KA3 蛋白), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (显示 CSF1R 蛋白) receptor at Tyr721 and, consequently, its binding to p85 (显示 ECM1 蛋白) subunit of PI3K and PI3K activation.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
MAPKs play a critical role in the control of cellular responses to cytokines and stressors and involved in the LPS (显示 TLR4 蛋白)-induced signaling pathway by which iNOS (显示 NOS2 蛋白) is expressed.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (显示 CRK 蛋白) Pathways and the Interaction with Cell-Surface-HSP70 (显示 HSP70 蛋白)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (显示 KITLG 蛋白) production probably through Ca(2 (显示 CA2 蛋白)+) -ERK (显示 EPHB2 蛋白)-AP-1 (显示 JUN 蛋白)-miR (显示 MLXIP 蛋白)-34c deregulation.
This indicates that TcpC may promote MIP2 (显示 CXCL2 蛋白) production in kidney cells through the p38 MAPK (显示 MAPK14 蛋白) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (显示 CXCL2 蛋白) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (显示 NF1 蛋白) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (显示 NF1 蛋白) (+/-) mice.
Stress-specific p38 MAPK (显示 MAPK14 蛋白) activation is sufficient to drive EGFR (显示 EGFR 蛋白) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (显示 EPHB2 蛋白)/Mitf (显示 MITF 蛋白) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
The present results suggest that demecolcine might contribute to the activation of the Mos (显示 MOCOS 蛋白)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (显示 CSN2 蛋白) synthesis through the Stat5 (显示 STAT5A 蛋白) and mTOR (显示 FRAP1 蛋白) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (显示 CDK1 蛋白) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (显示 MSLN 蛋白)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (显示 THBS1 蛋白), fibronectin (显示 FN1 蛋白), and vitronectin (显示 VTN 蛋白) are differentially dependent upon RAS, ERK1/2, and p38 (显示 MAPK14 蛋白) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 蛋白) nuclear accumulation.
Role of CaMKII (显示 CAMK2G 蛋白) in hydrogen peroxide activation of p38 MAPK (显示 MAPK14 蛋白)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
MAPK1 role in the oocyte maturation
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (显示 ITK 蛋白) in colon cancer.
ERK1/2-Akt1 (显示 AKT1 蛋白) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (显示 SH3GL1 蛋白) plays an important role in the development of the myeloid cell through activation of the ERK1 (显示 MAPK3 蛋白)/ERK2 pathway
ERK1 (显示 MAPK3 蛋白) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (显示 HSPA1A 蛋白) in response to heat stress is dependent on ERK activation in Pac2 (显示 PSMG2 蛋白) cells.
Data define distinct roles for ERK1 (显示 MAPK3 蛋白) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (显示 MSLN 蛋白) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (显示 DUSP1 蛋白) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (显示 DUSP1 蛋白) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (显示 MAPK3 蛋白)- and MPK6 (显示 MAPK6 蛋白)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (显示 FYN 蛋白) activity, which, in turn, increases MKP-1 (显示 DUSP1 蛋白) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (显示 EDN1 蛋白) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (显示 MAPK14 蛋白) kinase-mediated production of superoxide from NADPH oxidase (显示 NOX1 蛋白) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (显示 CSF2 蛋白) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (显示 FRAP1 蛋白) signal transduction cascades.
PGRN (显示 GRN 蛋白) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (显示 PPARG 蛋白) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (显示 MAPK8 蛋白)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2