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|抗原||Mitogen-Activated Protein Kinase 1 (MAPK1) 抗体|
|抗原表位||AA 219-358 其他选择|
|适用||小鸡, 犬, Frog, 人, 小鼠, 大鼠 其他选择|
|标记||This ERK2 antibody is un-conjugated 其他选择|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
ERK2抗体详情ERK2目标详情 使用细节 贮存及处理 References for anti-ERK2 antibody (ABIN967748) 图像
|交叉反应||人, 犬, 小鼠, 小鸡, Frog|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|纯化方法||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|免疫原||Rat ERK2 aa. 219-358|
ERK2目标详情ERK2抗体详情 使用细节 贮存及处理 References for anti-ERK2 antibody (ABIN967748) 图像 回页首
|别名||ERK2 (MAPK1 Antibody 摘要)|
|背景||The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a wide variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. Structural analysis of ERK2 indicates that phosphorylation induces a conformational change that exposes the active site for substrate binding. Myriad proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK2 is the 42kDa member of the ERK family and is highly homologous to ERK1.|
|途径||MAPK Pathway, RTK signaling, Apoptosis, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals|
使用细节ERK2抗体详情 ERK2目标详情 贮存及处理 References for anti-ERK2 antibody (ABIN967748) 图像 回页首
Related Products: ABIN967389
贮存及处理ERK2抗体详情 ERK2目标详情 使用细节 References for anti-ERK2 antibody (ABIN967748) 图像 回页首
|缓冲液||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store undiluted at -20°C.|
References for anti-ERK2 antibody (ABIN967748)ERK2抗体详情 ERK2目标详情 使用细节 贮存及处理 图像 回页首
Kim, Ju, Oh, Yoon, Song, Kim, Yoo, Bang, Kang, Chun: "ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status." in: The Journal of biological chemistry, Vol. 277, Issue 2, pp. 1332-9, 2002
Lehmann, Janda, Pierreux, Rytömaa, Schulze, McMahon, Hill, Beug, Downward: "Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells." in: Genes & development, Vol. 14, Issue 20, pp. 2610-22, 2000
Liu, Tsai, Aird: "Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor." in: Blood, Vol. 96, Issue 5, pp. 1772-81, 2000
Lund-Johansen, Davis, Bishop, de Waal Malefyt: "Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions." in: Cytometry, Vol. 39, Issue 4, pp. 250-9, 2000
Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, 2000
图像ERK2抗体详情 ERK2目标详情 使用细节 贮存及处理 References for anti-ERK2 antibody (ABIN967748) 回页首