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Human EIF4EBP1 Protein expressed in Escherichia coli (E. coli) - ABIN2001934
Hara, Maruki, Long, Yoshino, Oshiro, Hidayat, Tokunaga, Avruch, Yonezawa: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. in Cell 2002
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Using an mTORspecific signalling pathway phospho array we revealed that NVPBEZ235 significantly decreased phosphorylation of 4EBP1 (Thr70), the downstream target of mTORC1.
These results demonstrate a previously unrecognized role of IL24 (显示 IL24 蛋白) in inhibition of translation, mediated through both phosphorylation of eIF2alpha (显示 EIF2A 蛋白) and dephosphorylation of 4E-BP1, and provide the first direct evidence for translation control of gene-specific expression by IL24 (显示 IL24 蛋白)
High p-4E-BP1 expression was significantly associated with lymphovascular invasion (LVI) (p=0.003), perineural invasion (PNI (显示 SERPINE2 蛋白)) (p=0.001), tumor stage (p=0.024), nodal stage (p=0.000), metastatic status (p=0.027), and disease stage (p=0.001).
Numerous protein kinases can be responsible for mTOR (显示 FRAP1 蛋白) independent 4E-BP1 phosphorylation in cancer. (Review)
PI3K (显示 PIK3CA 蛋白) kinase activity is necessary for maintaining 4E-BP1 stability. Our results also suggest 4E-BP1 a novel biological role of regulating cell cycle G2 checkpoint in responding to IR stress in association with controlling CHK2 (显示 CHEK2 蛋白) phosphorylation
Findings suggest that mitotic CDK1 (显示 CDK1 蛋白)-directed phosphorylation of delta-4E-BP1 may yield a gain of function, distinct from translation regulation, that may be important in tumorigenesis and mitotic centrosome function.
p4EBP1 was independently predictive for pathologic complete response in PIK3CA (显示 PIK3CA 蛋白) wild-type tumors.
Data show that 4EGI-1 compound induced apoptosis in nasopharyngeal carcinoma cells through the death receptor 5 (DR5 (显示 TNFRSF10B 蛋白)) on 4E-BP1 dephosphorylation exerting positive influence on their anti-tumor activities.
There were significantly higher expressions of p-eIF4E (显示 EIF4E 蛋白) and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis.
4E-BP1 has tumor suppressor activity by inhibiting eIF4E (显示 EIF4E 蛋白) and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers
4E-BP proteins may prevent excess lipid accumulation in skeletal muscle and suggest that 4E-BPs are key regulators of muscle homeostasis regardless of insulin (显示 INS 蛋白) sensitivity.
our results show that the phosphorylation of 4E-BP1 promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 (显示 CDK1 蛋白) and mTOR (显示 FRAP1 蛋白) kinases in this process
Lack of Def6 (显示 DEF6 蛋白) results in deregulation of Bcl6 (显示 BCL6 蛋白) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E (显示 EIF4E 蛋白) axis.
decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1.
we show that simultaneous inhibition of mTOR (显示 FRAP1 蛋白) signaling to both S6K1 (显示 RPS6KB1 蛋白) and 4E-BP1 is sufficient to reduce AKT (显示 AKT1 蛋白)-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
4E-BP1 is a gender-specific suppressor of obesity that regulates insulin (显示 INS 蛋白) sensitivity and energy metabolism.
The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E (显示 EIF4E 蛋白)) interaction and eukaryotic initiation factor (显示 EIF4G1 蛋白) 4F (eIF4F (显示 EIF4A2 蛋白)) complex formation to support viral growth and viral protein expression.
p-mTOR (显示 FRAP1 蛋白), p-4EBP1, HIF-1alpha (显示 HIF1A 蛋白) and VEGF (显示 VEGFA 蛋白) together are involved in the pathogenesis of asthma.
Thus, translational control by 4E-BP1 downstream of mTOR (显示 FRAP1 蛋白) effects the expression of neuroligin 1 (显示 NLGN1 蛋白) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.
The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.
4E-BP determines lifespan in the context of temperature changes, revealing a genetic mechanism for cold-induced longevity in this model organism. Our results suggest that the 4E-BP pathway, chiefly thought of as a nutrient sensor, may represent a master metabolic switch responding to diverse environmental factors
Here, the authors show that cell autonomous insulin (显示 INS 蛋白) signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin (显示 INS 蛋白) utilizes the FOXO-dependent regulation of the thor gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP).
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
longevity assurance mutants of chico, the Drosophila insulin receptor (显示 INSR 蛋白) substrate homolog, require Drosophila d4eBP to slow aging.
These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (显示 EIF4E 蛋白) to repress translation.
PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression
These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.
Induction of 4EBP likely leads to growth inhibition by Dfoxo, whereas activation of InR (显示 INSR 蛋白) provides a novel transcriptionally induced feedback control mechanism.
S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (显示 FRAP1 蛋白)-RPS6K-RPS6 (显示 RPS6 蛋白)-EIF4EBP1 signal transduction pathway.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
eIF4E-binding protein 1
, eukaryotic translation initiation factor 4E-binding protein 1
, phosphorylated heat- and acid-stable protein regulated by insulin 1
, Eif4e-binding protein
, eIF-4E-binding protein
, eif4e-binding protein 4EBP
, eukaryotic initiation factor 4E binding protein
, eukaryotic initiation factor 4E-binding protein
, eukaryotic translation initiation factor 4E binding protein
, eukaryotic translation initiation factor 4E-binding protein
, insulin-stimulated eIF-4E binding protein
, lethal (2) 06270
, eukaryotic translation initiation factor 4E binding protein 1
, translation initiation factor 4E binding protein 1